Panahizadeh Reza, Vatankhah Mohammad Amin, Safari Ali, Danesh Hesam, Nazmi Negin, Gholizadeh Pourya, Soozangar Narges, Jeddi Farhad
Zoonoses Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Department of Orthopedics, Shohada Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Cancer Cell Int. 2024 Jul 5;24(1):234. doi: 10.1186/s12935-024-03430-1.
MicroRNAs (miRNAs), as a class of nonprotein-coding RNAs, post-transcriptionally regulate the expression of target genes by base pairing to 3'-untranslated regions (3'-UTRs). Nuclear factor E2-related factor 2 (Nrf2) has been identified as a critical component of the antioxidant defense mechanism. Dysregulation is associated with chemoresistance and radioresistance in cancerous cells. MiRNA-mediated regulation of the Nrf2 signaling pathway has been shown to have important implications for the development of various cancers. In this article, we review the roles of miRNAs as regulators of the Nrf2 pathway in different human cancers. Ras-associated binding (Rab) proteins have an essential role regulation of vesicle transport, as well as oncogenic functions in preventing chemotherapy efficacy and cancer development. More importantly, increased evidence indicated that the interaction between miRNAs and Rabs has been determined to play critical roles in cancer therapy. However, the significant limitations in using miRNAs for therapeutic applications include cross-targeting and instability of miRNAs. The detailed aspect of the interaction of miRNAs and Rabs is not clearly understood. In the current review, we highlighted the involvement of these molecules as regulators of the Nrf2 pathway in cancer pathogenesis. Potential methods and several obstacles in developing miRNAs as an anticancer therapy are also mentioned.
微小RNA（miRNA）作为一类非蛋白质编码RNA，通过与3'非翻译区（3'-UTR）碱基配对在转录后调节靶基因的表达。核因子E2相关因子2（Nrf2）已被确定为抗氧化防御机制的关键组成部分。失调与癌细胞的化疗耐药性和放射抗性有关。miRNA介导的Nrf2信号通路调节已被证明对各种癌症的发展具有重要意义。在本文中，我们综述了miRNA作为Nrf2通路调节剂在不同人类癌症中的作用。Ras相关结合（Rab）蛋白在囊泡运输调节中起重要作用，以及在阻止化疗疗效和癌症发展方面具有致癌功能。更重要的是，越来越多的证据表明，miRNA与Rab之间的相互作用已被确定在癌症治疗中起关键作用。然而，将miRNA用于治疗应用的重大局限性包括miRNA的交叉靶向和不稳定性。miRNA与Rab相互作用的详细方面尚不清楚。在当前的综述中，我们强调了这些分子作为Nrf2通路调节剂在癌症发病机制中的作用。还提到了开发miRNA作为抗癌疗法的潜在方法和一些障碍。
