Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, P.O. Box 48175-861 Sari 4847193698, Iran.
Department of Biology, Faculty of Biological Sciences, Parand Branch of Islamic Azad University, P.O. Box 37613-96361, Parand, Tehran, Iran.
Bioresour Technol. 2024 Aug;406:131072. doi: 10.1016/j.biortech.2024.131072. Epub 2024 Jul 5.
Immobilized laccases are widely used as green biocatalysts for bioremediation of phenolic pollutants and wastewater treatment. Metal-organic frameworks (MOFs) show potential application for immobilization of laccase. Their unique adsorption properties provide a synergic effect of adsorption and biodegradation. This review focuses on bioremediation of wastewater pollutants using laccase-MOF composites, and summarizes the current knowledge and future perspective of their biodegradation and the enhancement strategies of enzyme immobilization. Mechanistic strategies of preparation of laccase-MOF composites were mainly investigated via physical adsorption, chemical binding, and de novo/co-precipitation approaches. The influence of architecture of MOFs on the efficiency of immobilization and bioremediation were discussed. Moreover, as sustainable technology, the integration of laccases and MOFs into wastewater treatment processes represents a promising approach to address the challenges posed by industrial pollution. The MOF-laccase composites can be promising and reliable alternative to conventional techniques for the treatment of wastewaters containing pharmaceuticals, dyes, and phenolic compounds. The detailed exploration of various immobilization techniques and the influence of MOF architecture on performance provides valuable insights for optimizing these composites, paving the way for future advancements in environmental biotechnology. The findings of this research have the potential to influence industrial wastewater treatment and promoting cleaner treatment processes and contributing to sustainability efforts.
固定化漆酶被广泛用作生物修复酚类污染物和废水处理的绿色生物催化剂。金属-有机框架（MOFs）显示出用于固定化漆酶的潜在应用。它们独特的吸附性能提供了吸附和生物降解的协同作用。本综述重点介绍了使用漆酶-MOF 复合材料进行废水污染物的生物修复，并总结了它们生物降解的现有知识和未来展望以及酶固定化的增强策略。漆酶-MOF 复合材料的制备机制策略主要通过物理吸附、化学结合和从头/共沉淀方法进行了研究。讨论了 MOFs 的结构对固定化和生物修复效率的影响。此外，作为可持续技术，将漆酶和 MOFs 整合到废水处理工艺中代表了应对工业污染所带来挑战的一种有前途的方法。MOF-漆酶复合材料是处理含有药物、染料和酚类化合物的废水的传统技术的有前途且可靠的替代方法。对各种固定化技术的详细探索以及 MOF 结构对性能的影响为优化这些复合材料提供了有价值的见解，为环境生物技术的未来发展铺平了道路。这项研究的结果有可能影响工业废水处理，并促进更清洁的处理过程，为可持续发展做出贡献。
