神经酰胺在新陈代谢的中枢控制中。
Ceramides in the central control of metabolism.
作者信息
López Miguel, Diéguez Carlos, Tena-Sempere Manuel, González-García Ismael
机构信息
Department of Physiology, CiMUS, University of Santiago de Compostela, Santiago de Compostela, 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain.
Department of Physiology, CiMUS, University of Santiago de Compostela, Santiago de Compostela, 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain.
出版信息
Trends Endocrinol Metab. 2025 Jan;36(1):11-14. doi: 10.1016/j.tem.2024.06.007. Epub 2024 Jul 6.
Central ceramides regulate energy metabolism by impacting hypothalamic neurons. This allows ceramides to integrate endocrine signals - such as leptin, ghrelin, thyroid hormones, or estradiol - and to modulate the central control of puberty. In this forum article we discuss recent evidence suggesting that specific ceramide species and neuronal populations are involved in these effects.
中枢神经酰胺通过影响下丘脑神经元来调节能量代谢。这使得神经酰胺能够整合诸如瘦素、胃饥饿素、甲状腺激素或雌二醇等内分泌信号，并调节青春期的中枢控制。在这篇论坛文章中，我们讨论了最近的证据，这些证据表明特定的神经酰胺种类和神经元群体参与了这些作用。
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