Department of Chemistry, The University of Adelaide, North Terrace, Adelaide, SA, 5005, Australia.
Chempluschem. 2024 Nov;89(11):e202400305. doi: 10.1002/cplu.202400305. Epub 2024 Aug 23.
Peptide nucleic acids (PNAs) combine the programmability of native nucleic acids with the robustness and ease of synthesis of a peptide backbone. These designer biomolecules have demonstrated tremendous utility across a broad range of applications, from the formation of bespoke biosupramolecular architectures to biosensing and gene regulation. Herein, we explore some of the key developments in the application of PNA in chemical biology and biotechnology in the last 5 years and present anticipated key areas of future development.
肽核酸（PNAs）将天然核酸的可编程性与肽骨架的稳健性和易于合成相结合。这些设计生物分子在广泛的应用中表现出了巨大的实用性，从定制生物超分子结构的形成到生物传感和基因调控。本文探讨了过去 5 年中 PNA 在化学生物学和生物技术中的一些关键应用，并提出了未来预期的关键发展领域。
