Medical College of Tibet University, Lasa 850000, China; Laboratory of Radiation Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
Laboratory of Radiation Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
Environ Int. 2024 Mar;185:108535. doi: 10.1016/j.envint.2024.108535. Epub 2024 Feb 27.
Ultraviolet (UV) radiation is ubiquitous in the environment, which has been classified as an established human carcinogen. As the largest and outermost organ of the body, direct exposure of skin to sunlight or UV radiation can result in sunburn, inflammation, photo-immunosuppression, photoaging and even skin cancers. To date, there are tactics to protect the skin by preventing UV radiation and reducing the amount of UV radiation to the skin. Nevertheless, deciphering the essential regulatory mechanisms may pave the way for therapeutic interventions against UV-induced skin disorders. Additionally, UV light is considered beneficial for specific skin-related conditions in medical UV therapy. Recent evidence indicates that the biological effects of UV exposure extend beyond the skin and include the treatment of inflammatory diseases, solid tumors and certain abnormal behaviors. This review mainly focuses on the effects of UV on the skin. Moreover, novel findings of the biological effects of UV in other organs and systems are also summarized. Nevertheless, the mechanisms through which UV affects the human organism remain to be fully elucidated to achieve a more comprehensive understanding of its biological effects.
紫外线（UV）辐射在环境中无处不在，已被归类为已确立的人类致癌物。作为人体最大和最外层的器官，皮肤直接暴露于阳光或 UV 辐射下会导致晒伤、炎症、光免疫抑制、光老化甚至皮肤癌。迄今为止，有一些策略可以通过防止 UV 辐射和减少皮肤接受的 UV 辐射量来保护皮肤。然而，破译基本的调节机制可能为针对 UV 诱导的皮肤疾病的治疗干预铺平道路。此外，UV 光被认为对医学 UV 疗法中特定的与皮肤相关的病症有益。最近的证据表明，UV 照射的生物学效应不仅局限于皮肤，还包括治疗炎症性疾病、实体瘤和某些异常行为。本综述主要关注 UV 对皮肤的影响。此外，还总结了 UV 在其他器官和系统中产生的生物学效应的新发现。然而，要全面了解其生物学效应，仍需阐明 UV 影响人体的机制。
