• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Exploring the mechanism of saponin in inhibiting the inflammatory response of microglia in cerebral ischemia based on network pharmacology.

作者信息

Duan Zhaoda, Jia Wenji, Wang Jianxiang, Xu Dongyao, Yang Yujia, Qi Zhi, Yang Li, Wu Chunyun

机构信息

Department of Anatomy and Histology/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China.

Department of Neurology, No.2 Affiliated Hospital, Kunming Medical University, Kunming 650101, China.

出版信息

Acta Biochim Biophys Sin (Shanghai). 2024 Jul 5;56(10):1566-1570. doi: 10.3724/abbs.2024114.

DOI:10.3724/abbs.2024114
PMID:38973343
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11532199/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/926d/11532199/06e774de27c4/ABBS-2024-173-t3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/926d/11532199/54ca5a1e7eb0/ABBS-2024-173-t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/926d/11532199/897e8512331f/ABBS-2024-173-t2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/926d/11532199/06e774de27c4/ABBS-2024-173-t3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/926d/11532199/54ca5a1e7eb0/ABBS-2024-173-t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/926d/11532199/897e8512331f/ABBS-2024-173-t2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/926d/11532199/06e774de27c4/ABBS-2024-173-t3.jpg

相似文献

1
Exploring the mechanism of saponin in inhibiting the inflammatory response of microglia in cerebral ischemia based on network pharmacology.基于网络药理学探讨皂苷抑制脑缺血中微胶质细胞炎症反应的机制
Acta Biochim Biophys Sin (Shanghai). 2024 Jul 5;56(10):1566-1570. doi: 10.3724/abbs.2024114.
2
[Characterization analysis technique of Panax notoginseng saponin subcomponents for prevention and treatment of myocardial ischemia based on their structure and effect differences].基于三七皂苷各组分结构与效应差异的三七皂苷预防和治疗心肌缺血的表征分析技术
Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(12):2891-2902. doi: 10.19540/j.cnki.cjcmm.20200328.307.
3
[Mechanism of astragaloside Ⅳ combined with Panax notoginseng saponins in regulating angiogenesis to treat cerebral ischemia based on network pharmacology and experimental verification].基于网络药理学和实验验证探讨黄芪甲苷联合三七总皂苷调控血管生成治疗脑缺血的机制
Zhongguo Zhong Yao Za Zhi. 2024 Feb;49(4):1017-1027. doi: 10.19540/j.cnki.cjcmm.20230901.401.
4
[Research on Chinese medicine pairs effects of Panax notoginseng and Bletilla striata before and after compatibility on contents of notoginsenosides].[三七与白及配伍前后对三七总皂苷含量影响的中药药对研究]
Zhongguo Zhong Yao Za Zhi. 2016 Mar;41(5):887-890. doi: 10.4268/cjcmm20160521.
5
Network pharmacology and fingerprint for the integrated analysis of mechanism, identification and prediction in Panax notoginseng.网络药理学与指纹图谱用于三七作用机制综合分析、成分鉴定及预测
Phytochem Anal. 2023 Oct;34(7):772-787. doi: 10.1002/pca.3195. Epub 2022 Dec 8.
6
Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury via inhibiting HIF-1α/PKM2/STAT3 signaling.三七总皂苷通过抑制 HIF-1α/PKM2/STAT3 信号通路减轻小胶质细胞激活引起的炎症反应，保护缺血性脑损伤。
Biomed Pharmacother. 2022 Nov;155:113479. doi: 10.1016/j.biopha.2022.113479. Epub 2022 Oct 8.
7
Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy.基于网络药理学的三七治疗糖尿病视网膜病变的作用机制研究。
Comb Chem High Throughput Screen. 2020;23(4):334-344. doi: 10.2174/1386207323666200305093709.
8
Metabolomes and transcriptomes revealed the saponin distribution in root tissues of and .代谢组和转录组揭示了[植物名称1]和[植物名称2]根组织中的皂苷分布情况。
J Ginseng Res. 2020 Nov;44(6):757-769. doi: 10.1016/j.jgr.2019.05.009. Epub 2019 May 29.
9
Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology.三七总皂苷：抗抑郁或抗焦虑作用机制的综述及基于植物化学和药理学的网络分析。
Molecules. 2018 Apr 17;23(4):940. doi: 10.3390/molecules23040940.
10
Mechanism of Panax notoginseng saponins in improving cognitive impairment induced by chronic sleep deprivation based on the integrative analysis of serum metabolomics and network pharmacology.基于血清代谢组学和网络药理学的整合分析，探讨三七总皂苷改善慢性睡眠剥夺诱导认知障碍的作用机制。
J Ethnopharmacol. 2025 Jan 30;337(Pt 3):118988. doi: 10.1016/j.jep.2024.118988. Epub 2024 Oct 22.

引用本文的文献

1
Targeting microglia polarization with Chinese herb-derived natural compounds for neuroprotection in ischemic stroke.利用中药来源的天然化合物靶向小胶质细胞极化以实现缺血性脑卒中的神经保护
Front Cell Dev Biol. 2025 Jun 10;13:1580479. doi: 10.3389/fcell.2025.1580479. eCollection 2025.

本文引用的文献

1
Evaluation on the Efficacy and Safety of Panax Notoginseng Saponins in the Treatment of Stroke among Elderly People: A Systematic Review and Meta-Analysis of 206 Randomized Controlled Trials.三七总皂苷治疗老年脑卒中的疗效与安全性评价：一项对206项随机对照试验的系统评价与Meta分析
Evid Based Complement Alternat Med. 2023 May 4;2023:4312489. doi: 10.1155/2023/4312489. eCollection 2023.
2
Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula.网络药理学，揭示中药方剂药理学机制的一种有前途的方法。
J Ethnopharmacol. 2023 Jun 12;309:116306. doi: 10.1016/j.jep.2023.116306. Epub 2023 Feb 27.
3
Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Blume in the treatment of ischemic stroke.
关于梅花草治疗缺血性中风的分子靶点及机制的网络药理学和分子对接分析
Exp Ther Med. 2022 Nov 3;24(6):742. doi: 10.3892/etm.2022.11678. eCollection 2022 Dec.
4
PubChem 2023 update.PubChem 2023 更新。
Nucleic Acids Res. 2023 Jan 6;51(D1):D1373-D1380. doi: 10.1093/nar/gkac956.
5
Inflammatory Responses After Ischemic Stroke.缺血性中风后的炎症反应。
Semin Immunopathol. 2022 Sep;44(5):625-648. doi: 10.1007/s00281-022-00943-7. Epub 2022 Jun 29.
6
A Network Pharmacology Approach for Exploring the Mechanisms of Saponins in Ischaemic Stroke.一种基于网络药理学的方法探索皂苷治疗缺血性中风的机制
Evid Based Complement Alternat Med. 2021 Aug 13;2021:5582782. doi: 10.1155/2021/5582782. eCollection 2021.
7
Role of Purinergic Signalling in Endothelial Dysfunction and Thrombo-Inflammation in Ischaemic Stroke and Cerebral Small Vessel Disease.嘌呤能信号在缺血性脑卒中及脑小血管病中的内皮功能障碍和血栓-炎症中的作用
Biomolecules. 2021 Jul 6;11(7):994. doi: 10.3390/biom11070994.
8
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.芦荟大黄素通过 PI3K/AKT/mTOR 和 NF-κB 通路预防缺血性中风引起的神经损伤和神经炎症。
Food Funct. 2021 Sep 7;12(17):8056-8067. doi: 10.1039/d1fo01144h. Epub 2021 Jul 20.
9
Scutellarin Exerts Anti-Inflammatory Effects in Activated Microglia/Brain Macrophage in Cerebral Ischemia and in Activated BV-2 Microglia Through Regulation of MAPKs Signaling Pathway.野黄芩苷通过调控 MAPKs 信号通路在脑缺血激活的小胶质细胞/脑巨噬细胞和激活的 BV-2 小胶质细胞中发挥抗炎作用。
Neuromolecular Med. 2020 Jun;22(2):264-277. doi: 10.1007/s12017-019-08582-2. Epub 2019 Dec 2.
10
Qingnao dripping pills mediate immune-inflammatory response and MAPK signaling pathway after acute ischemic stroke in rats.清脑滴丸对大鼠急性缺血性脑卒中后免疫炎症反应及 MAPK 信号通路的影响
J Pharmacol Sci. 2019 Mar;139(3):143-150. doi: 10.1016/j.jphs.2018.12.009. Epub 2019 Jan 22.