Marx R E, Johnson R P, Kline S N
J Am Dent Assoc. 1985 Jul;111(1):49-54. doi: 10.14219/jada.archive.1985.0074.
A prospective randomized trial comparing hyperbaric oxygen and systemic antibiotics in the prevention of osteoradionecrosis was presented. The results indicated, in a high-risk population who required tooth removal in irradiated mandibles, that up-front hyperbaric oxygen produced an incidence of osteoradionecrosis of 5.4% as compared with the antibiotic group of 29.9% (P = .005). Hyperbaric oxygen should be considered a prophylactic measure when post-irradiation dental care involving trauma to tissue is necessary.
一项比较高压氧与全身抗生素预防放射性骨坏死的前瞻性随机试验被展示。结果表明，在需要拔除受照射下颌骨牙齿的高危人群中，预先使用高压氧导致放射性骨坏死的发生率为5.4%，而抗生素组为29.9%（P = 0.005）。当涉及组织创伤的放疗后牙科护理必要时，高压氧应被视为一种预防措施。
