Wilson Stefan L, Schulte Klaus-Martin, Steins Anne, Gruen Russell L, Tucker Emma M, van Loon Lex M
College of Health and Medicine, Australian National University, Canberra, ACT, Australia.
Front Physiol. 2024 Jun 21;15:1351985. doi: 10.3389/fphys.2024.1351985. eCollection 2024.
The space tourism industry is growing due to advances in rocket technology. Privatised space travel exposes non-professional astronauts with health profiles comprising underlying conditions to microgravity. Prior research has typically focused on the effects of microgravity on human physiology in healthy astronauts, and little is known how the effects of microgravity may play out in the pathophysiology of underlying medical conditions, such as heart failure. This study used an established, controlled lumped mathematical model of the cardiopulmonary system to simulate the effects of entry into microgravity in the setting of heart failure with both, reduced and preserved ejection fraction. We find that exposure to microgravity eventuates an increased cardiac output, and in patients with heart failure there is an unwanted increase in left atrial pressure, indicating an elevated risk for development of pulmonary oedema. This model gives insight into the risks of space flight for people with heart failure, and the impact this may have on mission success in space tourism.
由于火箭技术的进步，太空旅游业正在发展。私营化的太空旅行使具有潜在健康问题的非专业宇航员暴露于微重力环境中。先前的研究通常集中于微重力对健康宇航员人体生理的影响，而对于微重力在诸如心力衰竭等潜在疾病的病理生理学中如何发挥作用却知之甚少。本研究使用一个既定的、可控的心肺系统集总数学模型，来模拟在射血分数降低和保留的情况下，心力衰竭患者进入微重力环境的影响。我们发现，暴露于微重力环境会导致心输出量增加，而心力衰竭患者的左心房压力会出现不必要的升高，这表明发生肺水肿的风险增加。该模型有助于深入了解心力衰竭患者太空飞行的风险，以及这可能对太空旅游任务成功产生的影响。
