Veronica R M, Nelwan E J, Kumalawati J, Rumende C M, Chen K, Simadibrata M, Shatri H, Yunir E
University of Indonesia / RS dr. Cipto Mangunkusumo, Jakarta, Indonesia.
Ann Burns Fire Disasters. 2024 Jun 30;37(2):159-168. eCollection 2024 Jun.
Susceptibility to infection and increased antibiotic resistance place burn patients at risk of infection caused by multidrug-resistant organisms (MDRO). This condition can progress to sepsis, which can increase morbidity and mortality. A retrospective cohort study using medical record data of patients treated at RSUPN dr. Cipto Mangunkusumo in the period January 2020 to June 2022 was conducted. Of a total 160 subjects in the study period, 82.5% were aged <60 years, 16.88% had comorbidities, the most common cause of burns was fire (86.25%), the use of medical devices was 90.63%, with a median length of stay of 14 days. The most common Gram-negative MDRO pathogens were (29.91%), (22.32%) and (20.54%): 45% of MDRO infected patients died. Bivariate analysis was conducted to find the effect of MDRO infection on burn patient mortality (RR 1,103; 95% CI 1,004-1,211, p=0.046). After adjusting for the role variables, namely: age, comorbidities, TBSA, use of medical devices, length of stay and multivariate analysis, it was found that the variables that had an effect on MDRO infection mortality were length of stay and age. MDRO infection has an effect on the mortality rate of burn patients. Mortality of burn patients due to MDRO infection is greater (45%) compared to non MDRO (21.43%). The most common Gram-negative MDRO pathogen is
感染易感性和抗生素耐药性增加使烧伤患者面临由多重耐药菌（MDRO）引起感染的风险。这种情况可能进展为脓毒症，进而增加发病率和死亡率。我们进行了一项回顾性队列研究，使用了2020年1月至2022年6月期间在RSUPN dr. Cipto Mangunkusumo接受治疗的患者的病历数据。在研究期间的总共160名受试者中，82.5%年龄<60岁，16.88%患有合并症，最常见的烧伤原因是火灾（86.25%），医疗器械使用率为90.63%，中位住院时间为14天。最常见的革兰氏阴性MDRO病原体是……（29.91%）、……（22.32%）和……（20.54%）：45%的MDRO感染患者死亡。进行双变量分析以发现MDRO感染对烧伤患者死亡率的影响（相对危险度1,103；95%置信区间1,004 - 1,211，p = 0.046）。在对角色变量进行调整后，即：年龄、合并症、烧伤总面积、医疗器械使用情况、住院时间并进行多变量分析，发现对MDRO感染死亡率有影响的变量是住院时间和年龄。MDRO感染对烧伤患者的死亡率有影响。与非MDRO感染（21.43%）相比，MDRO感染导致的烧伤患者死亡率更高（45%）。最常见的革兰氏阴性MDRO病原体是
