Di Rosa Viviana, Frigato Elena, Negrini Pietro, Cristiano Walter, López-Olmeda Jose Fernando, Rétaux Sylvie, Sánchez-Vázquez Francisco Javier, Foulkes Nicholas S, Bertolucci Cristiano
Department of Physiology, Faculty of Biology, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.
Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy.
iScience. 2024 Jun 4;27(7):110171. doi: 10.1016/j.isci.2024.110171. eCollection 2024 Jul 19.
The circadian clock represents a key timing system entrained by various periodic signals that ensure synchronization with the environment. Many investigations have pointed to the existence of two distinct circadian oscillators: one regulated by the light-dark cycle and the other set by feeding time. Blind cavefish have evolved under extreme conditions where they completely lack light exposure and experience food deprivation. Here, we have investigated feeding regulated clocks in two cavefish species, the Somalian cavefish and the Mexican cavefish , in comparison with the surface-dwelling zebrafish . Our results reveal that feeding represents an extremely strong synchronizer for circadian locomotor rhythmicity in subterranean cavefish. Indeed, we showed that consuming just one meal every 4 days is sufficient to entrain circadian rhythmicity in both cavefish species, but not in zebrafish. These profound adaptations to an extreme environment provide insight into the connections between feeding and circadian clocks.
昼夜节律钟是一种关键的计时系统，受各种周期性信号的调节，确保与环境同步。许多研究指出存在两种不同的昼夜节律振荡器：一种受明暗周期调节，另一种由进食时间设定。盲穴鱼在极端条件下进化，它们完全缺乏光照且经历食物匮乏。在此，我们研究了两种穴鱼——索马里穴鱼和墨西哥穴鱼——与地表栖息的斑马鱼相比，受进食调节的生物钟。我们的结果表明，进食是地下穴鱼昼夜运动节律的极强同步器。事实上，我们发现每4天仅进食一餐就足以使两种穴鱼的昼夜节律同步，但斑马鱼不行。这些对极端环境的深刻适应为进食与昼夜节律钟之间的联系提供了见解。
