Vijayakumar Goutham, Sundaram Gidean A, Kumar Santhosh P, Lakshmanan Saravanan, Krishnan Murugesan, Krishna Vinod K
Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 Jun 8;16(6):e61946. doi: 10.7759/cureus.61946. eCollection 2024 Jun.
Introduction Postoperative wound healing is the most important factor in the outcome of any surgical procedure. Wound healing is a dynamic process involving inflammation, neovascularization, granulation, fibroblast proliferation, re-epithelization, and remodeling. It repairs tissue integrity, restoring the body's natural defense barrier. A hastened wound healing will help in the quicker re-establishment of the body's homeostasis. includes vital nutrients and bioactive substances such as minerals, vitamins, and antioxidants. Its primary active ingredient papain causes the enzymatic debridement of wounds. Hemocoagulase is a thrombin-like serine protease that is mostly employed for its procoagulant and wound-healing characteristics. It is derived from the venom of species of snakes. This study aims to compare the wound-healing properties of topical leaf extract and Hemocoagulase after dental extractions. Materials & Methods For 48 patients requiring bilateral therapeutic dental extraction for orthodontic intervention, leaf extract (Caripill 275mg/5ml) was topically applied to the extraction socket on one side, and Hemocoagulase 0.2 CU solution (Botroclot) was applied to the extraction socket on the other side. The bilateral premolars were extracted for orthodontic treatment under local anesthesia. Patients were asked to apply the solution topically twice daily for seven days and were called for review on the seventh day. The assessment of the efficacy of both solutions in post-operative wound healing was the objective of the study. Healing was assessed by using a blinded single observer for all patients using Landry's healing index. Results A total of 48 subjects with 96 sites completed the study, with a mean age of 15.4 years. The study population consisted of 24 males and 24 females, which were evenly distributed among the two study groups. On comparison of wound healing index (WHI) scores between the two groups using the Wilcoxon signed rank test, Group A had a significantly higher mean rank than Group B with regards to the wound healing index score, and the results were statistically significant (p = 0.037). Conclusion It can be concluded from the study that leaf extract showed better wound healing in post-extraction sockets compared to Hemocoagulase. This study presents the promising use of natural extracts such as in wound healing because they are easily accessible to patients, more economical, and have no adverse reactions. More studies that focus on natural extracts to promote wound healing are required in the future.
引言 术后伤口愈合是任何外科手术结果的最重要因素。伤口愈合是一个动态过程，涉及炎症、新血管形成、肉芽组织形成、成纤维细胞增殖、再上皮化和重塑。它修复组织完整性，恢复身体的天然防御屏障。加速伤口愈合有助于更快地重建身体的内环境稳定。（此处原文缺失相关内容）包括重要营养素和生物活性物质，如矿物质、维生素和抗氧化剂。其主要活性成分木瓜蛋白酶可导致伤口的酶促清创。血凝酶是一种类似凝血酶的丝氨酸蛋白酶，主要因其促凝血和伤口愈合特性而被使用。它源自蛇类的毒液。本研究旨在比较拔牙后局部应用（此处原文缺失相关植物名称）叶提取物和血凝酶的伤口愈合特性。
材料与方法 对于48例因正畸干预需要进行双侧治疗性拔牙的患者，在一侧拔牙窝局部应用（此处原文缺失相关植物名称）叶提取物（Caripill 275mg/5ml），在另一侧拔牙窝应用0.2 CU溶液血凝酶（Botroclot）。在局部麻醉下拔除双侧前磨牙用于正畸治疗。要求患者每天局部应用该溶液两次，持续七天，并在第七天前来复查。本研究的目的是评估两种溶液在术后伤口愈合中的疗效。使用盲法单观察者对所有患者采用兰德里愈合指数评估愈合情况。
结果 共有48名受试者的96个部位完成了研究，平均年龄为15.4岁。研究人群包括24名男性和24名女性，平均分布在两个研究组中。使用Wilcoxon符号秩检验比较两组之间的伤口愈合指数（WHI）评分，就伤口愈合指数评分而言，A组的平均秩显著高于B组，结果具有统计学意义（p = 0.037）。
结论 从该研究可以得出结论，与血凝酶相比，（此处原文缺失相关植物名称）叶提取物在拔牙后牙槽窝显示出更好的伤口愈合效果。本研究表明（此处原文缺失相关植物名称）等天然提取物在伤口愈合方面具有广阔的应用前景，因为它们对患者来说容易获取、更经济且无不良反应。未来需要更多关注天然提取物促进伤口愈合的研究。
