Gupta Gauri, M R Muthusekhar, Kumar Santhosh P
Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha University, Chennai.
Cureus. 2018 Mar 30;10(3):e2398. doi: 10.7759/cureus.2398.
Extraction is one of the more common oral surgical procedures carried out in routine dental practice, and postextraction bleeding is a recognized, frequently encountered complication. It causes distress, agony, and discomfort to the patient. The aim of this systematic review was to analyze the existing literature and determine the efficacy of topical hemocoagulase as a hemostatic agent and its ability to reduce postoperative complications in comparison to routine saline pressure pack after the extraction of teeth. Information was collected from an electronic database (PubMed), and a manual search was also done in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology; International Journal of Oral and Maxillofacial Surgery; and the British Journal of Oral and Maxillofacial Surgery. Only those articles which met the inclusion criteria were selected. All studies and articles that compared topical hemocoagulase with saline pressure pack in patients requiring extraction of teeth were selected for review. Literature abstracts and full-text articles were analysed in this review. A total of four articles were included in this systematic review. All were randomized clinical trials that evaluated the clinical outcomes of topical hemocoagulase compared with saline pressure packs in extraction socket sites. A significant difference was present between the hemocoagulase group and control group (saline pressure pack) in relation to bleeding stoppage time, pain, swelling, wound healing, and other postoperative complications. Topical hemocoagulase is significantly effective in reducing bleeding, pain, and swelling after extraction of tooth when compared to saline pressure packs. It also acts as a promoter of wound healing.
拔牙术是常规牙科诊疗中较为常见的口腔外科手术之一，拔牙后出血是一种公认的、经常遇到的并发症。它会给患者带来痛苦、煎熬和不适。本系统评价的目的是分析现有文献，确定局部应用血凝酶作为止血剂的疗效，以及与拔牙后常规生理盐水压迫止血相比，其减少术后并发症的能力。从电子数据库（PubMed）收集信息，并在《口腔外科、口腔内科、口腔病理学、口腔放射学》《国际口腔颌面外科杂志》和《英国口腔颌面外科杂志》上进行了手工检索。仅选择符合纳入标准的文章。所有比较局部应用血凝酶与生理盐水压迫止血在拔牙患者中的研究和文章均被选入进行综述。本综述分析了文献摘要和全文文章。本系统评价共纳入4篇文章。所有文章均为随机临床试验，评估了在拔牙窝部位局部应用血凝酶与生理盐水压迫止血的临床效果。血凝酶组与对照组（生理盐水压迫止血）在止血时间、疼痛、肿胀、伤口愈合及其他术后并发症方面存在显著差异。与生理盐水压迫止血相比，局部应用血凝酶在拔牙后减少出血、疼痛和肿胀方面显著有效。它还可促进伤口愈合。
