Bergner-Rabinowitz S, Ferne M, Karshai H
Inflammation. 1979 Sep;3(4):417-29. doi: 10.1007/BF00913499.
The aim of the present study is to define that temporal relationships of the IgM and IgG responses to streptococcal group A carbohydrate (CHO) in rabbits and in man. Rabbits were immunized with group A streptococci and the development of anti-group A carbohydrate (ACHO) was studied. ACHO which appeared one week after the beginning of immunization belonged to the 19S class of immunoglobulins (IgM). A two- to four-fold rise in ACHO titers and immunoglobulins of the 7S class (IgG) were observed after two weeks. Three weeks after the beginning of immunization, the ACHO titer was at a maximum. In the following months no further rises in titer were seen, and the antibodies belonged mostly to the IgG class. IgM and IgG responses to streptococcal CHO and to extracellular antigens in patients with pharyngitis, acute rheumatic fever (ARF), and acute glomerulonephritis (AGN) were studied. Higher values of IgM were found in pharyngitis and AGN sera than in ARF sera, probably reflecting the interval between streprococcal infection and time of bleeding. ACHO antibodies persisted in patients' sera for long periods and belonged to IgG and IgM. This suggests a continuous, rather than a persistent, production of ACHO.
本研究的目的是确定兔和人对A组链球菌碳水化合物（CHO）的IgM和IgG反应的时间关系。用A组链球菌免疫兔子，并研究抗A组碳水化合物（ACHO）的产生情况。免疫开始一周后出现的ACHO属于19S类免疫球蛋白（IgM）。两周后观察到ACHO滴度和7S类免疫球蛋白（IgG）有两到四倍的升高。免疫开始三周后，ACHO滴度达到最高。在接下来的几个月里，滴度没有进一步升高，抗体大多属于IgG类。研究了咽炎、急性风湿热（ARF）和急性肾小球肾炎（AGN）患者对链球菌CHO和细胞外抗原的IgM和IgG反应。在咽炎和AGN血清中发现的IgM值高于ARF血清，这可能反映了链球菌感染与出血时间之间的间隔。ACHO抗体在患者血清中持续很长时间，且属于IgG和IgM。这表明ACHO是持续产生，而非持续性产生。
