Xiong Yanxiang, Pi Wenjun, Zhao Wang, Shi Weiwei, Yan Weihong, Yang Hao, Zhou Yuanrong, Li Qing, Yang Leiluo
Department of Traumatic Orthopedics, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Department of Medical Examination Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Front Cell Dev Biol. 2024 Jun 25;12:1426395. doi: 10.3389/fcell.2024.1426395. eCollection 2024.
Cerebrospinal fluid-contacting neurons (CSF-cNs) represent a distinct group of interneurons characterized by their prominent apical globular protrusions penetrating the spinal cord's central canal and their basal axons extending towards adjacent cells. Identified nearly a century back, the specific roles and attributes of CSF-cNs have just started to emerge due to the historical lack of definitive markers. Recent findings have confirmed that CSF-cNs expressing PKD2L1 possess attributes of neural stem cells, suggesting a critical function in the regeneration processes following spinal cord injuries. This review aims to elucidate the molecular markers of CSF-cNs as potential neural stem cells during spinal cord development and assess their roles post-spinal cord injury, with an emphasis on their potential therapeutic implications for spinal cord repair.
脑脊液接触神经元（CSF-cNs）是一类独特的中间神经元，其特征在于它们突出的顶端球状突起穿透脊髓中央管，以及它们的基底轴突向相邻细胞延伸。近一个世纪前就已被发现，但由于历史上缺乏明确的标志物，CSF-cNs的具体作用和特性才刚刚开始显现。最近的研究结果证实，表达多囊蛋白2样1（PKD2L1）的CSF-cNs具有神经干细胞的特性，这表明它们在脊髓损伤后的再生过程中发挥着关键作用。本综述旨在阐明CSF-cNs在脊髓发育过程中作为潜在神经干细胞的分子标志物，并评估它们在脊髓损伤后的作用，重点是它们对脊髓修复的潜在治疗意义。
