Zhang Haixin, Zhang Qile, Li Shicheng, Kong Fanzhen
Department of Human Anatomy, Binzhou Medical University, Yantai, China.
Glob Med Genet. 2025 May 16;12(3):100063. doi: 10.1016/j.gmg.2025.100063. eCollection 2025 Sep.
Post-Traumatic Stress Disorder (PTSD) represents a significant mental health challenge closely associated with the consequences of traumatic experiences. Recently, small extracellular vesicles (sEVs) have been recognized as vital elements in the facilitation of intercellular communication. This review delves into the potential roles and mechanisms of sEVs in PTSD, concentrating on their involvement in neural signaling, immune system reactions, and the modulation of molecular biomarkers related to psychological disorders. By integrating recent research outcomes, this article aims to provide fresh insights into the pathophysiological aspects of PTSD and investigate prospective therapeutic approaches, underlining the significance of sEVs within the broader context of stress-related conditions.
创伤后应激障碍（PTSD）是一项重大的心理健康挑战，与创伤经历的后果密切相关。最近，小细胞外囊泡（sEVs）已被视为促进细胞间通讯的关键要素。本综述深入探讨了sEVs在PTSD中的潜在作用和机制，重点关注它们在神经信号传导、免疫系统反应以及与心理障碍相关的分子生物标志物调节中的作用。通过整合近期研究成果，本文旨在为PTSD的病理生理学方面提供新的见解，并研究潜在的治疗方法，强调sEVs在更广泛的应激相关病症背景下的重要性。
