Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Alzheimers Dement. 2024 Aug;20(8):5578-5589. doi: 10.1002/alz.14071. Epub 2024 Jul 10.
Higher neuroticism might be associated with dementia risk. Here we investigated modification by genetic predisposition to dementia, mediation by mental health and vascular conditions, neuroimaging outcomes, and cognitive function.
Cox proportional-hazards models were used to assess the association between neuroticism score and incident dementia over up to 15 years in 1,74,164 participants. Cross-sectional analyses on dementia-related neuroimaging outcomes and cognitive function were conducted in 39,459 dementia-free participants.
Higher neuroticism was associated with an 11% higher risk of incident dementia, especially vascular dementia (15% higher risk), regardless of genetic predisposition to dementia. Mental and vascular conditions mediated the association of neuroticism with all-cause dementia and vascular dementia. Neuroticism was associated with higher cerebrovascular pathology, lower gray matter volume, and worse function across multiple cognitive domains.
Neuroticism could represent a risk factor for dementia, and vascular and mental health might drive these associations.
Neuroticism was associated with an increased risk of incident all-cause dementia, particularly vascular dementia. Associations were not modified by genetic predisposition to dementia. Associations were largely mediated by mental and vascular conditions. Neuroticism was associated with increased cerebrovascular pathology and lower gray matter volume. Neuroticism was associated with worse function across multiple cognitive domains.
较高的神经质可能与痴呆风险相关。在这里，我们研究了痴呆遗传易感性、心理健康和血管状况、神经影像学结果和认知功能的修饰作用。
使用 Cox 比例风险模型，在 174164 名参与者中，评估了神经质评分与长达 15 年的痴呆事件之间的关联。在 39459 名无痴呆参与者中进行了与痴呆相关的神经影像学结果和认知功能的横断面分析。
较高的神经质与痴呆事件的风险增加 11%相关，尤其是血管性痴呆（风险增加 15%），而与痴呆的遗传易感性无关。精神和血管状况介导了神经质与所有原因痴呆和血管性痴呆的关联。神经质与多种认知领域的脑血管病理学增加、灰质体积减少和功能下降有关。
神经质可能是痴呆的一个风险因素，而血管和心理健康可能会导致这些关联。
神经质与新发全因痴呆的风险增加相关，尤其是血管性痴呆。与痴呆的遗传易感性无关。关联在很大程度上受精神和血管状况的调节。神经质与脑血管病变增加和灰质体积减少有关。神经质与多个认知领域的功能下降有关。
