de Wilde J, Mertens C, Overø K F, Petersen H E
Acta Psychiatr Scand. 1985 Jul;72(1):89-96. doi: 10.1111/j.1600-0447.1985.tb02576.x.
In a double-blind trial, comprising 60 endogenously depressed patients, citalopram was compared with mianserin. Fifty-eight patients completed the 6-week trial period with ratings and side effect recordings at weeks 0, 1, 2, 4, and 6. Both drugs were administered as a single evening dose, 20-80 mg (most frequently 40 mg) for citalopram and 60-120 mg (most frequently 90 mg) for mianserin. CPRS (Subscale for Depression) total scores showed a highly significant reduction in both groups with a significant difference in favour of citalopram after 1 and 2 weeks. Based on the Global Evaluation of the Severity of Illness there were 18 complete and three partial responders on citalopram and 13 complete and four partial responders on mianserin. Six patients on citalopram and one patient on mianserin showed mild or moderate side effects, but no cardiovascular side effects were recorded. The authors conclude that citalopram is a safe antidepressant drug, presumably better than mianserin.
在一项包含60名内源性抑郁症患者的双盲试验中，将西酞普兰与米安色林进行了比较。58名患者完成了为期6周的试验期，并在第0、1、2、4和6周进行了评分及副作用记录。两种药物均在每晚单次给药，西酞普兰剂量为20 - 80毫克（最常用剂量为40毫克），米安色林剂量为60 - 120毫克（最常用剂量为90毫克）。CPRS（抑郁分量表）总分在两组中均显示出高度显著的降低，在第1周和第2周后，西酞普兰组有显著优势。根据疾病严重程度的整体评估，西酞普兰组有18名完全缓解者和3名部分缓解者，米安色林组有13名完全缓解者和4名部分缓解者。6名服用西酞普兰的患者和1名服用米安色林的患者出现了轻度或中度副作用，但未记录到心血管副作用。作者得出结论，西酞普兰是一种安全的抗抑郁药物，可能比米安色林更好。
