Wuhan Prevention and Treatment Center for Occupational Diseases (School of Public Health of Joint Training Base for Graduate Students, Hubei University of Medicine), Wuhan, Hubei, China.
School of Public Health, Hubei University of Medicine, Shiyan, Hubei, China.
Front Public Health. 2024 Jun 26;12:1383065. doi: 10.3389/fpubh.2024.1383065. eCollection 2024.
The study aimed to estimate the role of liver fibrosis in the association between occupational physical activity (OPA) and blood pressure (BP), which is modified by lifestyle factors.
The questionnaire survey and physical examination were completed among 992 construction workers in Wuhan, China. Associations between OPA or lifestyle factors and liver fibrosis indices and blood pressure were assessed using generalized additive models. The mediation analysis was used to evaluate the role of liver fibrosis in the association between OPA and lifestyle factors and BP.
Moderate/high OPA group workers had an increased risk of liver fibrosis [odds ratio (OR) = 1.69, 95% confidence intervals (CI): 1.16-2.47, < 0.05] compared with low OPA group workers. Smoking or drinking alcohol was related to liver fibrosis (aspartate aminotransferase to platelet ratio index: OR = 2.22, 95% CI: 1.07-4.62 or OR = 2.04, 95% CI: 1.00-4.15; < 0.05). Compared with non-drinkers, drinkers were related to a 2.35-mmHg increase in systolic blood pressure (95% CI: 0.09-4.61), and a 1.60-mmHg increase in diastolic blood pressure (95% CI: 0.08-3.13; < 0.05). We found a significant pathway, "OPA → liver fibrosis → blood pressure elevation," and lifestyle factors played a regulatory role in the pathway.
OPA or lifestyle factors were associated with liver fibrosis indices or BP in construction workers. Furthermore, the association between OPA and BP may be partially mediated by liver fibrosis; lifestyle factors strengthen the relationship between OPA and BP and the mediation role of liver fibrosis in the relationship.
本研究旨在评估肝纤维化在职业体力活动（OPA）与血压（BP）之间的关联中的作用，这种关联受生活方式因素的影响。
在中国武汉，对 992 名建筑工人进行了问卷调查和体检。使用广义加性模型评估 OPA 或生活方式因素与肝纤维化指标和血压之间的关联。采用中介分析评估肝纤维化在 OPA 与生活方式因素和 BP 之间的关联中的作用。
与低 OPA 组工人相比，中/高强度 OPA 组工人肝纤维化的风险增加（比值比[OR] = 1.69，95%置信区间[CI]：1.16-2.47， < 0.05）。吸烟或饮酒与肝纤维化有关（天冬氨酸氨基转移酶与血小板比值指数：OR = 2.22，95%CI：1.07-4.62 或 OR = 2.04，95%CI：1.00-4.15； < 0.05）。与非饮酒者相比，饮酒者的收缩压升高 2.35mmHg（95%CI：0.09-4.61），舒张压升高 1.60mmHg（95%CI：0.08-3.13； < 0.05）。我们发现了一条显著的途径，即“OPA→肝纤维化→血压升高”，生活方式因素在该途径中起调节作用。
OPA 或生活方式因素与建筑工人的肝纤维化指数或 BP 相关。此外，OPA 与 BP 之间的关联可能部分通过肝纤维化介导；生活方式因素加强了 OPA 与 BP 之间的关系以及肝纤维化在两者关系中的中介作用。
