Rosenberg J M, Levy R C, Cicmanec J F, Hedges J R, Burke B M
Ann Emerg Med. 1985 Oct;14(10):970-2. doi: 10.1016/s0196-0644(85)80239-0.
Single-dose antibiotic therapy for urinary tract infections in which no underlying structural or neurologic lesions are present holds the promise of greater patient compliance and convenience. We present the results of a study comparing a single intramuscular dose of a long-acting, third-generation cephalosporin, ceftriaxone, with a standard, five-day regimen of trimethoprim-sulfamethoxazole (TMS). Fifty-two patients were entered into the study. After randomization, 26 were assigned to the TMS group and 26 were assigned to the ceftriaxone group. Of the patients who completed the study, 13 of the TMS group had positive cultures at the time of initial presentation, and 20 of the ceftriaxone group had positive cultures. There was no statistical difference between the groups in symptoms of dysuria, hematuria, frequency, flank pain, and nocturia (alpha = .05). The physical parameters of age, blood pressure, pulse, and temperature were similar in the two groups (alpha = .05), as were the types of infecting organisms (alpha = .05). When comparing the two regimens, the ceftriaxone group cure rate (18 of 20, 90%) was not found to be significantly different from that of the TMS-treated control group (13 of 13) (alpha = .05).
对于不存在潜在结构或神经病变的尿路感染，单剂量抗生素疗法有望提高患者的依从性并带来更大便利。我们呈现了一项研究的结果，该研究比较了单次肌内注射长效第三代头孢菌素头孢曲松与标准的五日甲氧苄啶 - 磺胺甲恶唑（TMS）疗法。52名患者参与了该研究。随机分组后，26名被分配到TMS组，26名被分配到头孢曲松组。在完成研究的患者中，TMS组有13名在初次就诊时培养结果呈阳性，头孢曲松组有20名培养结果呈阳性。两组在尿痛、血尿、尿频、胁腹疼痛和夜尿症状方面无统计学差异（α = 0.05）。两组的年龄、血压、脉搏和体温等身体参数相似（α = 0.05），感染病原体类型也相似（α = 0.05）。比较两种疗法时，未发现头孢曲松组的治愈率（20例中的18例，90%）与TMS治疗的对照组（13例中的13例）有显著差异（α = 0.05）。
