There have been many studies on human head-neck biomechanical models in the last two decades, and the associated modelling techniques were constantly evolving at the same time. Computational approaches have been widely leveraged, in parallel to conventional physical tests, to investigate biomechanics and injuries of the head-neck system in fields like the automotive industry, orthopedic, sports medicine, etc. The purpose of this manuscript is to provide a global review of the existing knowledge related to the modelling approaches, structural and biomechanical characteristics, validation, and application of the present head-neck models. This endeavor aims to support further enhancements and validations in modelling practices, particularly addressing the lack of data for model validation, as well as to prospect future advances in terms of the topics. Seventy-four models subject to the proposed selection criteria are considered. Based on previously established and validated head-neck computational models, most of the studies performed in-depth investigations of included cases, which revolved around four specific subjects: physiopathology, treatment evaluation, collision condition, and sports injury. Through the review of the recent 20 years of research, the summarized modelling information indicated existing deficiencies and future research topics, as well as provided references for subsequent head-neck model development and application.