Falanga A, Gordon S G
Biochim Biophys Acta. 1985 Sep 20;831(1):161-5. doi: 10.1016/0167-4838(85)90165-7.
Cysteine proteinases that initiate coagulation in the absence of factor VII have been isolated from rabbit V2 carcinoma and from human amnion-chorion. Many of their biochemical properties, including a molecular weight of 68 000 and inhibition by iodoacetamide and mercury, are the same. In the paper we compare the isoelectric point, the amino acid composition and the carbohydrate content of human amnion-chorion procoagulant and cancer procoagulant. With the exception of minor differences in the amino acid composition, attributable in part to differences in species, the two proteins are closely homologous.
在缺乏因子VII的情况下启动凝血的半胱氨酸蛋白酶已从兔V2癌和人羊膜绒毛膜中分离出来。它们的许多生化特性，包括分子量为68000以及被碘乙酰胺和汞抑制，都是相同的。在本文中，我们比较了人羊膜绒毛膜促凝剂和癌促凝剂的等电点、氨基酸组成和碳水化合物含量。除了氨基酸组成上的微小差异（部分归因于物种差异）外，这两种蛋白质密切同源。
