Institute of Graduate Studies Clinical Embryology Master Program, Maltepe University, Istanbul, Turkey.
Department of Histology and Embryology, Faculty of Medicine, Maltepe University, Istanbul, Turkey.
Aging Male. 2024 Dec;27(1):2374724. doi: 10.1080/13685538.2024.2374724. Epub 2024 Jul 11.
The effect of paternal age on fertility remains unclear. This retrospective study aims to examine the impact of male age on semen parameters and the reproductive outcomes of men admitted to an infertility center over a 9-year period. A total of 8046 patients were included in the study. Men were divided into four age groups. The groups were evaluated for semen parameters and reproductive outcome. The 21-30 year group presented lower sperm concentrations in comparison to those aged 31-40 and 41-50, yet shared a similar concentration to those over 50 years of age. Moreover, grades A and B decreased significantly in men aged over 50 years. The highest progressive motility and normozoospermia were observed in the age group 31-40 years while men over 50 years of age had the highest rates of asthenozoospermia and oligoasthenozoospermia. Furthermore, live birth results were reported in 5583 of the patients who underwent intracytoplasmic sperm injection (ICSI) and were found highest between 31-40 years of age. To our knowledge, this is the largest study in Turkey focusing on male age-related semen parameters and ICSI pregnancy outcomes. The study demonstrates that age is a significant factor for semen quality and live birth.
父亲年龄对生育力的影响仍不清楚。本回顾性研究旨在探讨男性年龄对 9 年内不孕中心就诊男性精液参数和生殖结局的影响。共纳入 8046 例患者。将男性分为四组。评估各组的精液参数和生殖结局。21-30 岁组的精子浓度明显低于 31-40 岁和 41-50 岁组，但与 50 岁以上组相似。此外，50 岁以上男性的 A 级和 B 级明显减少。31-40 岁组的精子前向运动能力最高，正常形态精子数最高，而 50 岁以上组的弱精子症和少弱精子症发生率最高。此外，在接受胞浆内单精子注射（ICSI）的 5583 例患者中报告了活产结果，发现 31-40 岁组的活产率最高。据我们所知，这是土耳其最大的一项关于男性年龄相关精液参数和 ICSI 妊娠结局的研究。该研究表明，年龄是精液质量和活产的重要因素。
