Kasali O B, Schiefer H B, Hancock D S, Blakley B R, Tomar R S, Greenhalgh R
Can J Comp Med. 1985 Jul;49(3):319-22.
3-Acetyldeoxynivalenol was incorporated into a semisynthetic diet at levels of 2.5, 5, 10 or 20 ppm and fed to mice for up to 48 days. Body weights and feed consumption were determined, and blood samples for hematological evaluation were taken. Selected tissues were examined microscopically and the humoral immune response was assessed using the Jerne plaque assay. 3-Acetyldeoxynivalenol caused a dose-related depressed feed consumption within the first seven days and reduced body weight until day 14 when fed at levels up to 10 ppm. When fed at a level of 20 ppm, an initial depression in body weight gain and a general malaise were followed by a return to normal. At necropsy, no macroscopic or microscopic lesions could be found. The immune response was not significantly affected after seven or 14 days, but at 21 days, a dose-dependent enhanced response was observed. The findings indicate that, after an initial period of reduced feed intake, animals are apparently able to overcome the toxic effects of 3-acetyldeoxynivalenol.
将3-乙酰脱氧雪腐镰刀菌烯醇以2.5、5、10或20 ppm的水平添加到半合成日粮中，喂养小鼠长达48天。测定体重和采食量，并采集血液样本进行血液学评估。对选定的组织进行显微镜检查，并使用耶尔恩斑试验评估体液免疫反应。3-乙酰脱氧雪腐镰刀菌烯醇在最初七天内导致与剂量相关的采食量下降，在以高达10 ppm的水平喂养时，体重在第14天之前持续减轻。当以20 ppm的水平喂养时，体重增加最初下降且出现全身不适，随后恢复正常。尸检时，未发现宏观或微观病变。免疫反应在7天或14天后未受到显著影响，但在21天时，观察到剂量依赖性增强反应。研究结果表明，在最初采食量减少的时期之后，动物显然能够克服3-乙酰脱氧雪腐镰刀菌烯醇的毒性作用。
