Schiefer H B, Nicholson S, Kasali O B, Hancock D S, Greenhalgh R
Can J Comp Med. 1985 Jul;49(3):315-8.
Mice were killed 2, 4, 6, 12, 24, 48 and 96 hours after intragastrical administration of 0, 5, 10, 20, or 40 mg/kg body weight of 3-acetyldeoxynivalenol. The animals became clinically ill after 12 hours and some animals in the highest dose group died. Histological examination of duodenal crypts, thymus and spleen revealed, in all dose groups, presence of the characteristic lesions that are known to be produced by trichothecenes, but the intensity of lesions in the 40 mg group corresponded to lesions known to be caused by 4 mg/kg of T-2 toxin. A rabbit skin bioassay with 3-acetyldeoxynivalenol gave negative results on one occasion and a mild reaction to 100 to 500 micrograms/mL on another. It is concluded that 3-acetyldeoxynivalenol is considerably less toxic than T-2 toxin, but causes acute effects in the dividing cells of the body in a manner characteristic of trichothecenes.
给小鼠分别灌胃0、5、10、20或40毫克/千克体重的3-乙酰脱氧雪腐镰刀菌烯醇，在给药后2、4、6、12、24、48和96小时处死小鼠。动物在12小时后出现临床疾病症状，最高剂量组的一些动物死亡。对十二指肠隐窝、胸腺和脾脏进行组织学检查发现，在所有剂量组中均存在已知由单端孢霉烯族毒素产生的特征性病变，但40毫克组的病变强度与已知由4毫克/千克T-2毒素引起的病变相当。用3-乙酰脱氧雪腐镰刀菌烯醇进行的兔皮肤生物测定，一次结果为阴性，另一次对100至500微克/毫升有轻微反应。得出的结论是，3-乙酰脱氧雪腐镰刀菌烯醇的毒性远低于T-2毒素，但以单端孢霉烯族毒素特有的方式对机体的分裂细胞产生急性影响。
