Hayes M A, Bellamy J E, Schiefer H B
Can J Comp Med. 1980 Apr;44(2):203-18.
Changes in hematopoietic and lymphoid tissues of young Swiss mice fed a balanced semipurified diet containing T-2 toxin (20 ppm) were examined after one, two, three, four or six weeks. During the first three weeks of exposure of T-2 toxin, lymphoid tissues, bone marrow and splenic red pulp became hypoplastic, resulting in anemia, lymphopenia and eosinopenia. Subsequently, during continued exposure to T-2 toxin, hematopoietic cells regenerated in bone marrow and splenic red pulp and became hyperplastic by six weeks. Granulopoiesis and thrombopoiesis resumed in advance of erythropoiesis. All lymphoid tissues remained atrophic throughout the six week trial. Mice exposed to T-2 toxin also developed perioral dermatitis and hyperkeratosis with ulceration of the mucosa of the esophageal region of the stomach. These results indicated that young mice were susceptible to both the irritant and the hematopoietic-suppressive toxic effects of dietary T-2 toxin. However, supression of hematopoiesis was transient and did not lead to hematopoietic failure.
对喂食含20 ppm T-2毒素的平衡半纯化饮食的幼龄瑞士小鼠，在1周、2周、3周、4周或6周后检查其造血和淋巴组织的变化。在接触T-2毒素的前三周，淋巴组织、骨髓和脾红髓发育不全，导致贫血、淋巴细胞减少和嗜酸性粒细胞减少。随后，在持续接触T-2毒素期间，骨髓和脾红髓中的造血细胞再生，并在6周时增生。粒细胞生成和血小板生成在红细胞生成之前恢复。在整个6周的试验中，所有淋巴组织均保持萎缩状态。接触T-2毒素的小鼠还出现了口周皮炎和角化过度，伴有胃食管区域黏膜溃疡。这些结果表明，幼龄小鼠对饮食中T-2毒素的刺激和造血抑制毒性作用均敏感。然而，造血抑制是短暂的，并未导致造血功能衰竭。
