Rivkin Miriam, Banerjee Sumona, Guan Torrey, Hendrix Christian
Internal Medicine, Saint Louis University School of Medicine, St. Louis, USA.
Cureus. 2024 Jun 11;16(6):e62166. doi: 10.7759/cureus.62166. eCollection 2024 Jun.
Normal pressure hydrocephalus (NPH) is a syndrome that characteristically presents with progressive gait impairment, cognitive deficits, and urinary urgency or incontinence. We present a case of a 54-year-old male with a past medical history of alcohol use and no primary care provider with new-onset auditory hallucinations. The patient was found to have a marked enlargement of the supratentorial and infratentorial ventricles on both computed tomography (CT) and magnetic resonance imaging (MRI) and an opening pressure of 21 on the lumbar puncture, concerning for NPH. Clinically, there were signs of cognitive impairment due to memory and cognitive function loss, but the patient lacked gait disturbances or incontinence. Although not common, NPH may present with auditory hallucinations or delusions, as seen with our patient. In this case report, we emphasize the importance of annual cognitive assessments in order to evaluate atypical psychiatric manifestations of neurological disorders. Because clinical symptoms are more likely to be reversible when recognized early in the clinical course and the progression of these symptoms can be prevented with the placement of a ventriculoperitoneal (VP) shunt, it is of utmost importance to accurately recognize and diagnose NPH as early as possible. We also discuss the less commonly known markers of NPH on MRI.
正常压力脑积水(NPH)是一种以进行性步态障碍、认知缺陷以及尿急或尿失禁为典型表现的综合征。我们报告一例54岁男性病例,该患者有饮酒病史且无初级保健医生,出现新发幻听症状。经计算机断层扫描(CT)和磁共振成像(MRI)检查发现,该患者幕上和幕下脑室明显扩大,腰椎穿刺开放压力为21,怀疑为NPH。临床上,患者因记忆和认知功能丧失有认知障碍体征,但缺乏步态障碍或尿失禁症状。虽然不常见,但NPH可能会出现幻听或妄想,正如我们的患者所表现的那样。在本病例报告中,我们强调年度认知评估对于评估神经系统疾病非典型精神症状的重要性。由于临床症状在病程早期被识别时更有可能可逆,并且通过放置脑室腹腔(VP)分流管可以预防这些症状的进展,因此尽早准确识别和诊断NPH至关重要。我们还讨论了MRI上NPH较少为人所知的标志物。