Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.
A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Int J Mol Sci. 2022 Jun 14;23(12):6616. doi: 10.3390/ijms23126616.
Piezo1 channels are highly mechanically-activated cation channels that can sense and transduce the mechanical stimuli into physiological signals in different tissues including skeletal muscle. In this focused review, we summarize the emerging evidence of Piezo1 channel-mediated effects in the physiology of skeletal muscle, with a particular focus on the role of Piezo1 in controlling myogenic precursor activity and skeletal muscle regeneration and vascularization. The disclosed effects reported by pharmacological activation of Piezo1 channels with the selective agonist Yoda1 indicate a potential impact of Piezo1 channel activity in skeletal muscle regeneration, which is disrupted in various muscular pathological states. All findings reported so far agree with the idea that Piezo1 channels represent a novel, powerful molecular target to develop new therapeutic strategies for preventing or ameliorating skeletal muscle disorders characterized by an impairment of tissue regenerative potential.
Piezo1 通道是高度机械激活的阳离子通道，可在包括骨骼肌在内的不同组织中感知和转导机械刺激为生理信号。在本重点综述中，我们总结了 Piezo1 通道介导的骨骼肌生理学效应的新证据，特别关注 Piezo1 在控制成肌前体细胞活性以及骨骼肌再生和血管生成中的作用。用选择性激动剂 Yoda1 药理学激活 Piezo1 通道所报道的被揭示的作用表明 Piezo1 通道活性对骨骼肌再生有潜在影响，而在各种肌肉病理状态下这种活性受到破坏。到目前为止报告的所有发现都与 Piezo1 通道代表一种新的、强大的分子靶标这一观点一致，这为开发新的治疗策略以预防或改善组织再生潜能受损为特征的骨骼肌疾病提供了可能。
