Wang Gang, Liu Tao, He Wen-Ting
School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Digestive System Tumor Prevention and Treatment and Translational Medicine Engineering Innovation Center of Lanzhou University, Lanzhou University, Lanzhou 730000, Gansu Province, China.
World J Gastrointest Oncol. 2024 Jun 15;16(6):2826-2841. doi: 10.4251/wjgo.v16.i6.2826.
Gastrointestinal tumor organoids serve as an effective model for simulating cancer and have been applied in basic biology and preclinical research. Despite over a decade of development and increasing research achievements in this field, a systematic and comprehensive analysis of the research hotspots and future trends is lacking.
To address this problem by employing bibliometric tools to explore the publication years, countries/regions, institutions, journals, authors, keywords, and references in this field.
The literature was collected from Web of Science databases. CiteSpace-6.2R4, a widely used bibliometric analysis software package, was used for institutional analysis and reference burst analysis. VOSviewer 1.6.19 was used for journal co-citation analysis, author co-authorship and co-citation analysis. The 'online platform for bibliometric analysis (https://bibliometric.com/app)' was used to assess the total number of publications and the cooperation relationships between countries. Finally, we employed the bibliometric R software package (version R.4.3.1) in R-studio, for a comprehensive scientific analysis of the literature.
Our analysis included a total of 1466 publications, revealing a significant yearly increase in articles on the study of gastrointestinal tumor organoids. The United States ( = 393) and Helmholtz Association ( = 93) have emerged as the leading countries and institutions, respectively, in this field, with Hans Clevers and Toshiro Sato being the most contributing authors. The most influential journal in this field is Gastroenterology. The most impactful reference is "Long term expansion of epithelial organs from human colon, adenoma, adenocarcinoma, and Barrett's epithelium". Keywords analysis and citation burst analysis indicate that precision medicine, disease modeling, drug development and screening, and regenerative medicine are the most cutting-edge directions. These focal points were further detailed based on the literature.
This bibliometric study offers an objective and quantitative analysis of the research in this field, which can be considered as an important guide for next scientific research.
胃肠道肿瘤类器官是模拟癌症的有效模型，已应用于基础生物学和临床前研究。尽管该领域经过十多年的发展并取得了越来越多的研究成果，但仍缺乏对研究热点和未来趋势的系统全面分析。
通过使用文献计量工具来探索该领域的发表年份、国家/地区、机构、期刊、作者、关键词和参考文献，以解决这一问题。
从科学网数据库收集文献。使用广泛使用的文献计量分析软件包CiteSpace - 6.2R4进行机构分析和参考文献爆发分析。使用VOSviewer 1.6.19进行期刊共被引分析、作者共同作者和共被引分析。使用“文献计量分析在线平台(https://bibliometric.com/app)”评估出版物总数和国家之间的合作关系。最后，我们在R - studio中使用文献计量R软件包(版本R.4.3.1)对文献进行全面的科学分析。
我们的分析共纳入1466篇出版物，显示胃肠道肿瘤类器官研究的文章数量逐年显著增加。美国( = 393)和亥姆霍兹协会( = 93)分别成为该领域领先的国家和机构，汉斯·克莱弗斯和佐藤俊郎是贡献最大的作者。该领域最具影响力的期刊是《胃肠病学》。最具影响力的参考文献是“来自人类结肠、腺瘤、腺癌和巴雷特上皮的上皮器官的长期扩增”。关键词分析和引文爆发分析表明，精准医学、疾病建模、药物开发与筛选以及再生医学是最前沿的方向。基于文献对这些重点进行了进一步细化。
这项文献计量研究为该领域的研究提供了客观定量的分析，可被视为下一轮科学研究的重要指南。
