Hunan Key Laboratory of The Research and Development of Novel Pharmaceutical Preparations, The Hunan Provincial University Key Laboratory of The Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha, Hunan 410000, P.R. China.
Oncol Rep. 2024 Sep;52(3). doi: 10.3892/or.2024.8776. Epub 2024 Jul 12.
Cancer constitutes a multifaceted ailment characterized by the dysregulation of numerous genes and pathways. Among these, LIM domain only 7 (LMO7) has emerged as a significant player in various cancer types, garnering substantial attention for its involvement in tumorigenesis and cancer progression. This review endeavors to furnish a comprehensive discourse on the functional intricacies and mechanisms of LMO7 in cancer, with a particular emphasis on its potential as both a therapeutic target and prognostic indicator. It delves into the molecular attributes of LMO7, its implications in cancer etiology and the underlying mechanisms propelling its oncogenic properties. Furthermore, it underscores the extant challenges and forthcoming prospects in targeting LMO7 for combating cancer.
癌症是一种多方面的疾病,其特征是许多基因和途径的失调。在这些基因和途径中,LIM 结构域只有 7(LMO7)在各种癌症类型中表现出重要作用,因其参与肿瘤发生和癌症进展而受到广泛关注。本综述旨在全面论述 LMO7 在癌症中的功能复杂性和机制,特别强调其作为治疗靶点和预后指标的潜力。它深入探讨了 LMO7 的分子属性、在癌症病因学中的意义以及推动其致癌特性的潜在机制。此外,它强调了针对 LMO7 治疗癌症的现存挑战和未来前景。