n-3 多不饱和脂肪酸与高水平运动员稳定的一氧化氮代谢物有关。

n-3 Polyunsaturated Fatty Acids Are Associated with Stable Nitric Oxide Metabolites in Highly Trained Athletes.

机构信息

Institute of Physiology, Komi Science Centre, Ural Branch of the Russian Academy of Sciences, FRC Komi SC UB RAS, 50 Pervomayskaya Str., 167982 Syktyvkar, Russia.

出版信息

Cells. 2024 Jun 27;13(13):1110. doi: 10.3390/cells13131110.

DOI:10.3390/cells13131110

PMID:38994963

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11240318/

Abstract

BACKGROUND

The aim of this study was to investigate the relationships between levels of n-3 essential polyunsaturated fatty acids (n-3 PUFAs) and stable nitric oxide (NO) metabolites in the plasma of athletes.

METHODS

Highly trained cross-country skiers (males, = 39) were examined. The fatty acid profile of the total plasma lipids was determined by gas chromatography. The plasma NO level was studied by a colorimetric method via reaction with Griess reagent.

RESULTS

A widespread deficiency of essential n-3 PUFAs in the plasma of athletes (more than 80% of the subjects) was demonstrated in association with an imbalance in the levels of nitrates (NO) and nitrites (NO). A lower value of n-3 linolenic acid in the plasma (0.21 mol/%) was associated with a NO level below the normal range (n-3 C18:3 and NO Rs = 0.461; = 0.003). Higher levels of n-3 eicosapentaenoic acid (0.8 mol/%) were associated with a concentration of NO above the normal value (n-3 C20:5 and NO Rs = 0.449; = 0.004).

CONCLUSION

For the first time, the participation of essential n-3 PUFAs in the nitrite-nitrate pathway of NO synthesis in highly trained skiers was demonstrated.

摘要

背景

本研究旨在探讨运动员血浆中 n-3 必需多不饱和脂肪酸（n-3 PUFAs）水平与稳定的一氧化氮（NO）代谢物之间的关系。

方法

对 39 名经过高度训练的越野滑雪运动员进行了检查。通过气相色谱法确定总血浆脂质的脂肪酸谱。通过与格里斯试剂反应的比色法研究血浆 NO 水平。

结果

在运动员的血浆中普遍缺乏必需的 n-3 PUFAs（超过 80%的受试者），同时硝酸盐（NO）和亚硝酸盐（NO）水平失衡。血浆中 n-3 亚麻酸的较低值（0.21 mol%）与低于正常范围的 NO 水平相关（n-3 C18:3 和 NO Rs = 0.461； = 0.003）。较高水平的 n-3 二十碳五烯酸（0.8 mol%）与高于正常值的 NO 浓度相关（n-3 C20:5 和 NO Rs = 0.449； = 0.004）。