两名复杂性真菌感染患者长期应用瑞沙康唑治疗的安全性：来自意大利莱科医院的 2 个病例。
Safety of rezafungin as a long-term treatment option in two patients with complicated fungal infections: two cases from Lecco Hospital (Italy).
机构信息
Infectious Diseases Unit, Ospedale A. Manzoni ASST-Lecco, Lecco, Italy.
Infectious Diseases Unit, Università Vita-Salute S. Raffaele, Milano, Italy.
出版信息
Antimicrob Agents Chemother. 2024 Aug 7;68(8):e0075024. doi: 10.1128/aac.00750-24. Epub 2024 Jul 12.
Abstract
Rezafungin is an echinocandin characterized by a long elimination half-life which allows for weekly administration. It has been recently approved for the treatment of candidemia. Few data are available about the long-term use of rezafungin and its use for deep infections like endocarditis and osteomyelitis. We describe our experience with its prolonged use in two azole-resistant infections: a case of sacral osteomyelitis and a prosthetic valve endocarditis also involving a thoracic endovascular aneurysm repair.
摘要
雷萨凡辛是一种棘白菌素类药物，具有较长的消除半衰期，允许每周给药。它最近已被批准用于治疗念珠菌血症。关于雷萨凡辛的长期使用及其在心内膜炎和骨髓炎等深部感染中的应用的数据很少。我们描述了在两例唑类耐药感染中延长使用雷萨凡辛的经验：一例是骶骨骨髓炎，另一例是累及胸主动脉血管内修复术的人工瓣膜心内膜炎。
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