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它在这儿,它在那儿,真菌无处不在:一项使用瑞扎芬净治疗侵袭性念珠菌病的病例系列研究。

It's Here, It's There, There's Fungi Everywhere: A Case Series Utilizing Rezafungin for Invasive Candidiasis.

作者信息

Keck Jacob M, Dare Ryan K, Jenkins Mitchell B, Rico Juan C, Grisham Luke, McDonald Jennifer, Viteri Alina, Bradsher Robert W

机构信息

Department of Pharmacy, University of Arkansas for Medical Sciences, 4301 W. Markham St. #529, Little Rock, AR, 72205, USA.

Department of Medicine, Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.

出版信息

Infect Dis Ther. 2025 Apr;14(4):889-895. doi: 10.1007/s40121-025-01120-7. Epub 2025 Mar 11.

Abstract

Rezafungin is a long-acting echinocandin with broad coverage against Candida. Rezafungin has primarily been indicated for candidemia, with limited literature available on its use for infections outside of the bloodstream. Herein, three patient cases are presented from an academic medical center. Infectious processes presented include drug-resistant mucosal candidiasis, prosthetic joint infection, and candidemia involving Candida auris. In all three cases, patients received rezafungin. Clinical response was demonstrated in all patients as was tolerability of rezafungin. Together these cases provide further evidence for the use of rezafungin, including its use for treatment of invasive infections other than candidemia.

摘要

瑞扎芬净是一种长效棘白菌素,对念珠菌具有广泛的覆盖范围。瑞扎芬净主要用于治疗念珠菌血症,而关于其用于血流以外感染的文献有限。本文介绍了来自一家学术医疗中心的三例患者病例。所呈现的感染过程包括耐药性黏膜念珠菌病、人工关节感染以及涉及耳念珠菌的念珠菌血症。在所有三例病例中,患者均接受了瑞扎芬净治疗。所有患者均显示出临床反应,瑞扎芬净的耐受性也良好。这些病例共同为瑞扎芬净的使用提供了进一步的证据,包括其用于治疗除念珠菌血症以外的侵袭性感染。

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