Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, USA.
mBio. 2024 Aug 14;15(8):e0121124. doi: 10.1128/mbio.01211-24. Epub 2024 Jul 12.
Intracellular infection by a pathogen induces significant rewiring of host cell signaling and biological processes. Understanding how an intracellular pathogen such as modulates host cell metabolism with single-cell resolution has been challenged by the variability of infection within cultures and difficulties in separating host and parasite metabolic processes. A new study from Gallego-Lopez and colleagues (G. M. Gallego-López, E. C. Guzman, D. E. Desa, L. J. Knoll, M. C. Skala, mBio e00727-24, 2024, https://doi.org/10.1128/mbio.00727-24) applies a quantitative imaging approach to evaluate the host cell metabolism during intracellular infection with . This study provides important insights into host metabolic responses to infection and offers a valuable tool to dissect the mechanisms underlying parasite infection and pathophysiology.
病原体的细胞内感染会显著改变宿主细胞的信号转导和生物学过程。了解细胞内病原体（如 ）如何以单细胞分辨率调节宿主细胞代谢，受到培养物中感染的可变性和分离宿主和寄生虫代谢过程的困难的挑战。Gallego-Lopez 和同事的一项新研究（G. M. Gallego-López、E. C. Guzman、D. E. Desa、L. J. Knoll、M. C. Skala，mBio e00727-24，2024，https://doi.org/10.1128/mbio.00727-24）应用定量成像方法来评估细胞内感染 时宿主细胞的代谢。这项研究为宿主对 感染的代谢反应提供了重要的见解，并为剖析寄生虫感染和病理生理学的机制提供了有价值的工具。
