Center for Health and Performance, Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden
Center for Lifestyle Intervention, Sahlgrenska University Hospital, Gothenburg, Sweden.
Br J Sports Med. 2024 Nov 12;58(21):1244-1250. doi: 10.1136/bjsports-2023-107451.
To investigate the physical activity (PA) intensity associated with cardiometabolic health when considering the mediating role of cardiorespiratory fitness (CRF).
A subsample of males and females aged 50-64 years from the cross-sectional Swedish CArdioPulmonary bioImage Study was investigated. PA was measured by accelerometry and CRF by a submaximal cycle test. Cardiometabolic risk factors, including waist circumference, systolic blood pressure, high-density lipoprotein, triglycerides and glycated haemoglobin, were combined to a composite score. A mediation model by partial least squares structural equation modelling was used to analyse the role of CRF in the association between PA and the composite score.
The cohort included 4185 persons (51.9% female) with a mean age of 57.2 years. CRF mediated 82% of the association between PA and the composite score. The analysis of PA patterns revealed that moderate intensity PA explained most of the variation in the composite score, while vigorous intensity PA explained most of the variation in CRF. When including both PA and CRF as predictors of the composite score, the importance of vigorous intensity increased.
The highly interconnected role of CRF in the association between PA and cardiometabolic health suggests limited direct effects of PA on cardiometabolic health beyond its impact on CRF. The findings highlight the importance of sufficient PA intensity for the association with CRF, which in turn is linked to better cardiometabolic health.
当考虑心肺功能（CRF）的中介作用时，研究与心血管代谢健康相关的体力活动（PA）强度。
从横断面的瑞典心肺生物影像研究中，选择了年龄在 50-64 岁的男性和女性亚组进行研究。通过加速度计测量 PA，通过次最大循环测试测量 CRF。将心血管代谢风险因素（包括腰围、收缩压、高密度脂蛋白、甘油三酯和糖化血红蛋白）组合成一个综合评分。采用偏最小二乘结构方程模型的中介模型来分析 CRF 在 PA 与综合评分之间的关联中的作用。
该队列包括 4185 人（51.9%为女性），平均年龄为 57.2 岁。CRF 介导了 PA 与综合评分之间 82%的关联。PA 模式的分析表明，中等强度的 PA 解释了综合评分变化的大部分，而剧烈强度的 PA 解释了 CRF 变化的大部分。当将 PA 和 CRF 都作为综合评分的预测因素时，剧烈强度 PA 的重要性增加。
CRF 在 PA 与心血管代谢健康之间的关联中的高度相互作用表明，PA 对心血管代谢健康的直接影响有限，超出了其对 CRF 的影响。研究结果强调了足够的 PA 强度与 CRF 相关的重要性，而 CRF 又与更好的心血管代谢健康相关。
