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美国纽约布朗克斯资源匮乏人群中剖宫产对新生儿肠道微生物组的影响。

The effect of cesarean delivery on the neonatal gut microbiome in an under-resourced population in the Bronx, NY, USA.

机构信息

Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.

Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forch. 312, Bronx, NY, 10461, USA.

出版信息

BMC Pediatr. 2024 Jul 13;24(1):450. doi: 10.1186/s12887-024-04908-7.

DOI:10.1186/s12887-024-04908-7
PMID:38997672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11245842/
Abstract

BACKGROUND

Neonatal and early-life gut microbiome changes are associated with altered cardiometabolic and immune development. In this study, we explored Cesarean delivery effects on the gut microbiome in our high-risk, under-resourced Bronx, NY population.

RESULTS

Fecal samples from the Bronx MomBa Health Study (Bronx MomBa Health Study) were categorized by delivery mode (vaginal/Cesarean) and analyzed via 16 S rRNA gene sequencing at four timepoints over the first two years of life. Bacteroidota organisms, which have been linked to decreased risk for obesity and type 2 diabetes, were relatively reduced by Cesarean delivery, while Firmicutes organisms were increased. Organisms belonging to the Enterococcus genus, which have been tied to aberrant immune cell development, were relatively increased in the Cesarean delivery microbiomes.

CONCLUSION

Due to their far-reaching impact on cardiometabolic and immune functions, Cesarean deliveries in high-risk patient populations should be carefully considered.

摘要

背景

新生儿和生命早期肠道微生物组的变化与心血管代谢和免疫发育的改变有关。在这项研究中，我们探索了剖宫产对我们高风险、资源匮乏的纽约布朗克斯人群肠道微生物组的影响。

结果

来自布朗克斯 MomBa 健康研究（Bronx MomBa Health Study）的粪便样本按分娩方式（阴道/剖宫产）进行分类，并在生命的头两年的四个时间点通过 16S rRNA 基因测序进行分析。与肥胖和 2 型糖尿病风险降低相关的拟杆菌门生物体，通过剖宫产而相对减少，而厚壁菌门生物体则增加。与异常免疫细胞发育有关的肠球菌属生物体在剖宫产微生物组中相对增加。

结论

由于剖宫产对心血管代谢和免疫功能的深远影响，高危患者人群的剖宫产应谨慎考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/d13d66d8e0c5/12887_2024_4908_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/2f598afb06ad/12887_2024_4908_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/88db79be4a23/12887_2024_4908_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/8a29b3b113b0/12887_2024_4908_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/a1339f57bf9b/12887_2024_4908_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/0dd6ac33227f/12887_2024_4908_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/d13d66d8e0c5/12887_2024_4908_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/2f598afb06ad/12887_2024_4908_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/88db79be4a23/12887_2024_4908_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/8a29b3b113b0/12887_2024_4908_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/a1339f57bf9b/12887_2024_4908_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/0dd6ac33227f/12887_2024_4908_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/11245842/d13d66d8e0c5/12887_2024_4908_Fig6_HTML.jpg

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