Brogi Simone, Tabanelli Rita, Puca Sara, Calderone Vincenzo
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Foods. 2024 Jun 21;13(13):1960. doi: 10.3390/foods13131960.
Intermittent fasting (IF) has been indicated as a valuable alternative to the classical caloric restriction dietary regimen for lowering body weight and preventing obesity-related complications, such as metabolic syndrome and type II diabetes. However, is it effective? In this review article, we analyzed over 50 clinical studies in which IF, conducted by alternate day fasting (ADF) or time-restricted feeding (TRF), was compared with the caloric restriction approach. We evaluated the different roles of IF in treating and preventing human disorders such as metabolic syndrome, type II diabetes, and some types of cancer, as well as the usefulness of IF in reducing body weight and cardiovascular risk factors such as hypertension. Furthermore, we explored the cellular pathways targeted by IF to exert their beneficial effects by activating effector proteins that modulate cell functions and resistance to oxidative stress. In contrast, we investigated concerns regarding human health related to the adoption of IF dietary regimens, highlighting the profound debate surrounding weight loss regimens. We examined and compared several clinical trials to formulate an updated concept regarding IF and its therapeutic potential.
间歇性禁食（IF）已被视为传统热量限制饮食方案的一种有价值的替代方法，用于减轻体重和预防肥胖相关并发症，如代谢综合征和II型糖尿病。然而，它有效吗？在这篇综述文章中，我们分析了50多项临床研究，其中将通过隔日禁食（ADF）或限时进食（TRF）进行的间歇性禁食与热量限制方法进行了比较。我们评估了间歇性禁食在治疗和预防人类疾病（如代谢综合征、II型糖尿病和某些类型的癌症）中的不同作用，以及间歇性禁食在减轻体重和心血管危险因素（如高血压）方面的有效性。此外，我们探讨了间歇性禁食通过激活调节细胞功能和抗氧化应激抗性的效应蛋白来发挥其有益作用所靶向的细胞途径。相比之下，我们调查了与采用间歇性禁食饮食方案相关的人类健康问题，突出了围绕减肥方案的深刻辩论。我们检查并比较了几项临床试验，以形成关于间歇性禁食及其治疗潜力的最新概念。
