Grupo de Controle do Peso, Hospital 9 de Julho, São Paulo, SP, Brasil,
Departamento de Medicina Interna, Universidade do Estado de São Paulo (Unesp), Botucatu, SP, Brasil.
Arch Endocrinol Metab. 2021 Nov 1;65(1):14-23. doi: 10.20945/2359-3997000000322. Epub 2021 Jan 14.
Intermittent fasting (IF) is an increasingly popular method of weight loss, as an alternative to daily caloric restriction (DCR). Several forms of IF exist, such as alternate-day fasting or time-restricted feeding regimens. Some of its proponents claim several health benefits unrelated to caloric restriction or weight loss, which rely mainly on animal models. Although several studies published in the last few years confirm that IF can be a useful and safe therapeutical option for obesity and related disorders, no superiority to conventional caloric restriction diets have emerged. There are still several questions left answered. In this Review, we discuss some of the claims, unveiling myths, facts, and presumptions about several models of IF. The focus of this article is obesity, but there is a brief discussion of the potential benefits of IF on overall human health.
间歇性禁食（IF）作为一种替代每日热量限制（DCR）的减肥方法，越来越受到人们的欢迎。IF 有几种形式，如隔日禁食或限时喂养方案。它的一些支持者声称，IF 除了与热量限制或体重减轻无关的一些健康益处外，主要依赖于动物模型。尽管近年来发表的几项研究证实 IF 可以作为肥胖和相关疾病的一种有用且安全的治疗选择，但与传统的热量限制饮食相比，它并没有表现出优越性。仍有一些问题没有得到解答。在这篇综述中，我们讨论了 IF 的一些说法，揭示了关于 IF 的几种模式的一些误解、事实和假设。本文的重点是肥胖，但也简要讨论了 IF 对人类整体健康的潜在益处。
