Ośko Justyna, Nasierowska Katarzyna, Grembecka Małgorzata
Department of Bromatology, Faculty of Pharmacy, Medical University of Gdańsk, Gen. J. Hallera Avenue 107, 80-416 Gdańsk, Poland.
Student Scientific Circle, Department of Bromatology, Faculty of Pharmacy, Medical University of Gdańsk, Gen. J. Hallera Avenue 107, 80-416 Gdańsk, Poland.
Foods. 2024 Jul 4;13(13):2135. doi: 10.3390/foods13132135.
Nowadays, dietary supplements are a permanent part of our diet. Using various simulated in vitro digestive models, the bioavailability of dietary supplement ingredients has also been investigated. In most cases, static models are used instead of dynamic ones. This article focuses on the division of applications of in vitro methods, such as assessing the quality of dietary supplements (in chemical and pharmaceutical form), the impact of diet on the assessment of the bioavailability of product ingredients, the impact of supplement ingredients on the state of intestinal microflora, and the development of new products using various encapsulation methods. The review included publications from 2000 to 2024 showing the use of in vitro methods in dietary supplements containing polysaccharides, proteins, elements, vitamins, and bioactive substances, as well as probiotic and prebiotic products. The impact of components in dietary supplements on the human digestive tract and their degree of bioaccessibility were determined through the use of in vitro methods. The application of in vitro methods has also become an effective tool for designing new forms of dietary supplements in order to increase the availability and durability of labile ingredients in these products.
如今，膳食补充剂已成为我们饮食中不可或缺的一部分。通过各种体外模拟消化模型，人们也对膳食补充剂成分的生物利用度进行了研究。在大多数情况下，使用的是静态模型而非动态模型。本文重点介绍体外方法的应用领域，如评估膳食补充剂（化学和药物形式）的质量、饮食对产品成分生物利用度评估的影响、补充剂成分对肠道微生物群状态的影响，以及使用各种包封方法开发新产品。该综述涵盖了2000年至2024年的出版物，展示了体外方法在含有多糖、蛋白质、元素、维生素、生物活性物质的膳食补充剂以及益生菌和益生元产品中的应用。通过体外方法确定了膳食补充剂中成分对人体消化道的影响及其生物可及性程度。体外方法的应用也已成为设计新型膳食补充剂的有效工具，以提高这些产品中不稳定成分的利用率和稳定性。
