Department of Chemistry, School of Basic and Applied Sciences, K.R. Mangalam University, Gurugram, Haryana, India.
The Institute for Quantitative Health Sciences & Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, MI 48824, USA.
Curr Pharm Biotechnol. 2022;23(14):1721-1738. doi: 10.2174/1389201023666220110104645.
Among conventional treatment methodologies, surgery, hyperthermia, radiation, and chemotherapy have become integral components of treatment for most cancers. Radiation therapy in the treatment of many malignancies is always the better choice over surgery and chemotherapy. Ionizing radiation produced as a consequence of using these radiations has always been a concern in these treatment methods. Synthetic radio-protectors with their inherent limitations are being used to date to reduce the mortality of these radiations; still, it compromises the clinical efficacy of these administrations. Hence, investigations for alternative methods, including natural resources such as plant and fruit extracts, are being explored to treat radiation-mediated ailments. The present review article endeavors to provide a comprehensive, updated, and chronological account of these promising plants and fruit extracts and their bioactive principles as radio-protectors. We present the merits and demerits of radiation therapy and cell stress generation of reactive oxygen species (ROS) associated with radiation need and availability of radio-protectors. Finally, we discuss green-based bioactive compounds that have radioprotective properties.
在常规治疗方法中，手术、高热、放射和化学疗法已成为大多数癌症治疗的重要组成部分。在治疗许多恶性肿瘤时，放射疗法通常优于手术和化疗。使用这些射线产生的电离辐射一直是这些治疗方法中的一个关注点。迄今为止，合成的放射保护剂因其固有局限性而被用于降低这些射线的死亡率；但这会影响这些治疗的临床疗效。因此，人们正在探索替代方法，包括植物和水果提取物等天然资源，以治疗辐射介导的疾病。本文综述旨在全面、系统地阐述这些有前途的植物和水果提取物及其作为放射保护剂的生物活性成分。我们介绍了放射疗法的优缺点，以及与放射相关的细胞应激产生的活性氧（ROS）的需要和放射保护剂的可用性。最后，我们讨论了具有放射保护特性的基于绿色的生物活性化合物。
