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基于可生物降解聚酯酰胺的 PEG 化微/纳米粒子：基于同步辐射傅里叶变换红外显微镜和电子显微镜研究核壳结构的制备。

PEGylated Micro/Nanoparticles Based on Biodegradable Poly(Ester Amides): Preparation and Study of the Core-Shell Structure by Synchrotron Radiation-Based FTIR Microspectroscopy and Electron Microscopy.

机构信息

Departament de Enginyeria Química, Universitat Politècnica de Catalunya, EEBE, Av. Eduard Maristany 10-14, 08019 Barcelona, Spain.

Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Tbilisi 0159, Georgia.

出版信息

Int J Mol Sci. 2024 Jun 26;25(13):6999. doi: 10.3390/ijms25136999.

DOI:10.3390/ijms25136999
PMID:39000109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11241343/
Abstract

Surface modification of drug-loaded particles with polyethylene glycol (PEG) chains is a powerful tool that promotes better transport of therapeutic agents, provides stability, and avoids their detection by the immune system. In this study, we used a new approach to synthesize a biodegradable poly(ester amide) (PEA) and PEGylating surfactant. These were employed to fabricate micro/nanoparticles with a core-shell structure. Nanoparticle (NP)-protein interactions and self-assembling were subsequently studied by synchrotron radiation-based FTIR microspectroscopy (SR-FTIRM) and transmission electron microscopy (TEM) techniques. The core-shell structure was identified using IR absorption bands of characteristic chemical groups. Specifically, the stretching absorption band of the secondary amino group (3300 cm) allowed us to identify the poly(ester amide) core, while the band at 1105 cm (C-O-C vibration) was useful to demonstrate the shell structure based on PEG chains. By integration of absorption bands, a 2D intensity map of the particle was built to show a core-shell structure, which was further supported by TEM images.

摘要

载药粒子的表面用聚乙二醇（PEG）链进行修饰是一种强大的工具，它可以促进治疗剂更好的传输，提供稳定性，并避免被免疫系统检测到。在这项研究中，我们使用了一种新的方法来合成可生物降解的聚（酯酰胺）（PEA）和 PEG 化表面活性剂。这些物质被用来制备具有核壳结构的微/纳米粒子。通过基于同步辐射的傅里叶变换红外显微镜（SR-FTIRM）和透射电子显微镜（TEM）技术研究了纳米粒子（NP）-蛋白相互作用和自组装。通过特征化学基团的红外吸收带识别出核壳结构。具体来说，仲氨基（3300 cm）的伸缩吸收带允许我们识别出聚（酯酰胺）核，而 1105 cm 处的带（C-O-C 振动）则有助于基于 PEG 链显示壳结构。通过吸收带的积分，构建了粒子的 2D 强度图以显示核壳结构，这进一步得到 TEM 图像的支持。

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