等离子体纳米泡增强的内体逃逸过程，用于选择性和引导性地将化疗药物递送到耐药癌细胞内。
Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells.
机构信息
Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA.
出版信息
Biomaterials. 2012 Feb;33(6):1821-6. doi: 10.1016/j.biomaterials.2011.11.015. Epub 2011 Dec 2.
Abstract
Cancer chemotherapies suffer from multi drug resistance, high non-specific toxicity and heterogeneity of tumors. We report a method of plasmonic nanobubble-enhanced endosomal escape (PNBEE) for the selective, fast and guided intracellular delivery of drugs through a self-assembly by cancer cells of separately targeted gold nanoparticles and encapsulated drug (Doxil). The co-localized with Doxil plasmonic nanobubbles optically generated in cancer cells released the drug into the cytoplasm thus increasing the therapeutic efficacy against these drug-resistant cells by 31-fold, reducing drug dose by 20-fold, the treatment time by 3-fold and the non-specific toxicity by 10-fold compared to standard treatment. Thus the PNBEE mechanism provided selective, safe and efficient intracellular drug delivery in heterogeneous environment opening new opportunities for drug therapies.
摘要
癌症化疗存在多药耐药性、高非特异性毒性和肿瘤异质性等问题。我们报告了一种等离子体纳米泡增强内体逃逸（PNBEE）的方法，用于通过癌细胞对靶向金纳米颗粒和包裹药物（Doxil）的自组装，选择性、快速和引导性地将药物递送至细胞内。在癌细胞中光学产生的与 Doxil 共定位的等离子体纳米泡将药物释放到细胞质中，从而使这些耐药细胞的治疗效果提高 31 倍，药物剂量降低 20 倍，治疗时间缩短 3 倍，非特异性毒性降低 10 倍，与标准治疗相比。因此，PNBEE 机制在异质环境中提供了选择性、安全和有效的细胞内药物递送，为药物治疗开辟了新的机会。
相似文献
1
Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells.等离子体纳米泡增强的内体逃逸过程，用于选择性和引导性地将化疗药物递送到耐药癌细胞内。
Biomaterials. 2012 Feb;33(6):1821-6. doi: 10.1016/j.biomaterials.2011.11.015. Epub 2011 Dec 2.
2
Tunable plasmonic nanobubbles for cell theranostics.可调谐等离子体纳米气泡用于细胞治疗学。
Nanotechnology. 2010 Feb 26;21(8):85102. doi: 10.1088/0957-4484/21/8/085102. Epub 2010 Jan 25.
3
Plasmonic nanobubbles rapidly detect and destroy drug-resistant tumors.等离子体纳米气泡能快速检测和破坏耐药肿瘤。
Theranostics. 2012;2(10):976-87. doi: 10.7150/thno.5116. Epub 2012 Oct 13.
4
Plasmonic photothermal release of docetaxel by gold nanoparticles incorporated onto halloysite nanotubes with conjugated 2D8-E3 antibodies for selective cancer therapy.金纳米粒子负载于 2D8-E3 抗体偶联的埃洛石纳米管用于光热治疗的载药研究
J Nanobiotechnology. 2021 Aug 11;19(1):239. doi: 10.1186/s12951-021-00982-6.
5
Release of photoactivatable drugs from plasmonic nanoparticles for targeted cancer therapy.等离子体纳米颗粒释放光激活药物用于靶向癌症治疗。
ACS Nano. 2011 Oct 25;5(10):7796-804. doi: 10.1021/nn201592s. Epub 2011 Oct 3.
6
Methods for Generation and Detection of Nonstationary Vapor Nanobubbles Around Plasmonic Nanoparticles.等离激元纳米颗粒周围非稳态蒸汽纳米气泡的产生与检测方法。
Methods Mol Biol. 2017;1530:165-192. doi: 10.1007/978-1-4939-6646-2_11.
7
Accelerating the multifunctionalization of therapeutic nanoparticles by using a multicomponent reaction.通过使用多组分反应加速治疗性纳米粒子的多功能化。
Chemistry. 2012 Apr 27;18(18):5501-5. doi: 10.1002/chem.201103743. Epub 2012 Mar 21.
8
Remote triggered release of doxorubicin in tumors by synergistic application of thermosensitive liposomes and gold nanorods.热敏感脂质体和金纳米棒协同应用于肿瘤中阿霉素的远程触发释放。
ACS Nano. 2011 Jun 28;5(6):4919-26. doi: 10.1021/nn201010q. Epub 2011 Jun 2.
9
Single Pulse Nanosecond Laser-Stimulated Targeted Delivery of Anti-Cancer Drugs from Hybrid Lipid Nanoparticles Containing 5 nm Gold Nanoparticles.单脉冲纳秒激光刺激载有 5nm 金纳米粒子的混合脂质纳米粒子靶向递抗癌药物。
Small. 2023 Dec;19(52):e2305591. doi: 10.1002/smll.202305591. Epub 2023 Nov 7.
10
Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk-Shell Structure Augment Cancer Chemotherapy.具有核壳结构的细胞膜包覆纳米粒子增强癌症化学疗法。
Nano Lett. 2020 Feb 12;20(2):936-946. doi: 10.1021/acs.nanolett.9b03817. Epub 2019 Nov 5.
引用本文的文献
1
Nanosecond Laser Pulses Facilitating Efficient and Specific Cell Killing with Doxorubicin-Loaded Gold Nanoparticles Targeted to the Folate Receptor.纳秒激光脉冲联合靶向叶酸受体的载阿霉素金纳米颗粒实现高效特异性细胞杀伤
Small Sci. 2024 Dec 19;5(2):2400234. doi: 10.1002/smsc.202400234. eCollection 2025 Feb.
2
Investigating the Potential of CO Nanobubble Systems for Enhanced Oil Recovery in Extra-Low-Permeability Reservoirs.研究一氧化碳纳米气泡系统在超低渗透油藏提高采收率方面的潜力。
Nanomaterials (Basel). 2024 Jul 30;14(15):1280. doi: 10.3390/nano14151280.
3
Amalgamation of Nanoparticles within Drug Carriers: A Synergistic Approach or a Futile Attempt?药物载体中纳米颗粒的融合：一种协同方法还是徒劳尝试？
Pharm Nanotechnol. 2022 Sep 2. doi: 10.2174/2211738510666220902150449.
4
Liquid-Infused Microgrooved Slippery Surface Ablated by One-Step Laser Irradiation for Underwater Bubble Directional Manipulation and Anisotropic Spreading.通过一步激光辐照烧蚀制备的注入液体的微槽光滑表面用于水下气泡定向操纵和各向异性扩展
Micromachines (Basel). 2021 May 13;12(5):555. doi: 10.3390/mi12050555.
5
Multifunctional nanoclusters of NaYF:Yb,Er upconversion nanoparticle and gold nanorod for simultaneous imaging and targeted chemotherapy of bladder cancer.上转换纳米粒子 NaYF:Yb,Er 和金纳米棒的多功能纳米簇用于膀胱癌的同时成像和靶向化疗。
Mater Sci Eng C Mater Biol Appl. 2019 Apr;97:784-792. doi: 10.1016/j.msec.2018.12.113. Epub 2018 Dec 29.
6
Membrane reorganization after photochemical internalization to release transferrin-biofunctionalized polystyrene microparticles.光化学内吞作用后释放转铁蛋白生物功能化聚苯乙烯微球的膜重排。
Sci Rep. 2018 Dec 4;8(1):17617. doi: 10.1038/s41598-018-35913-3.
7
Photothermally Triggered Endosomal Escape and Its Influence on Transfection Efficiency of Gold-Functionalized JetPEI/pDNA Nanoparticles.金功能化 JetPEI/pDNA 纳米颗粒的光热触发内涵体逃逸及其对转染效率的影响。
Int J Mol Sci. 2018 Aug 14;19(8):2400. doi: 10.3390/ijms19082400.
8
In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles.用于筛选药物和纳米颗粒转运的肿瘤微环境体外微流控模型。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Sep;9(5). doi: 10.1002/wnan.1460. Epub 2017 Feb 14.
9
The role of morphology and coupling of gold nanoparticles in optical breakdown during picosecond pulse exposures.皮秒脉冲照射期间金纳米颗粒的形态和耦合在光学击穿中的作用。
Beilstein J Nanotechnol. 2016 Jun 16;7:869-80. doi: 10.3762/bjnano.7.79. eCollection 2016.
10
Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers.通过内体逃逸增强剂提高免疫毒素和其他靶向蛋白毒素的疗效
Toxins (Basel). 2016 Jul 1;8(7):200. doi: 10.3390/toxins8070200.
本文引用的文献
1
Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs.基于囊泡融合的多核囊泡纳米粒子用于化疗药物递送。
Biomaterials. 2011 Nov;32(31):7924-31. doi: 10.1016/j.biomaterials.2011.07.017. Epub 2011 Jul 23.
2
Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells.阿霉素偶联响应性金纳米颗粒促进细胞内药物递送，克服癌细胞的多药耐药性。
ACS Nano. 2011 May 24;5(5):3679-92. doi: 10.1021/nn200007z. Epub 2011 Apr 12.
3
Partially polymerized liposomes: stable against leakage yet capable of instantaneous release for remote controlled drug delivery.部分聚合脂质体：既稳定防止泄漏，又能够瞬时释放，用于远程控制药物输送。
Nanotechnology. 2011 Apr 15;22(15):155605. doi: 10.1088/0957-4484/22/15/155605. Epub 2011 Mar 10.
4
Selective gene transfection of individual cells in vitro with plasmonic nanobubbles.利用等离子体纳米气泡对体外单个细胞进行选择性基因转染。
J Control Release. 2011 Jun 10;152(2):286-93. doi: 10.1016/j.jconrel.2011.02.006. Epub 2011 Feb 17.
5
Recent developments in lipid-based pharmaceutical nanocarriers.脂质体药物纳米载体的最新进展。
Front Biosci (Landmark Ed). 2011 Jan 1;16(4):1388-412. doi: 10.2741/3795.
6
Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line.介孔二氧化硅纳米粒子的工程设计，以递送阿霉素和 P-糖蛋白 siRNA，以克服癌细胞系中的药物耐药性。
ACS Nano. 2010 Aug 24;4(8):4539-50. doi: 10.1021/nn100690m.
7
The in vivo performance of plasmonic nanobubbles as cell theranostic agents in zebrafish hosting prostate cancer xenografts.载瘤斑马鱼模型中用于癌症治疗与诊断的等离子体纳米气泡的体内性能。
Biomaterials. 2010 Oct;31(29):7567-74. doi: 10.1016/j.biomaterials.2010.06.031. Epub 2010 Jul 14.
8
Gold-embedded photosensitive liposomes for drug delivery: triggering mechanism and intracellular release.载金光敏脂质体用于药物传递：触发机制和细胞内释放。
J Control Release. 2010 Oct 1;147(1):136-43. doi: 10.1016/j.jconrel.2010.07.095. Epub 2010 Jul 16.
9
The correlation between acoustic cavitation and sonoporation involved in ultrasound-mediated DNA transfection with polyethylenimine (PEI) in vitro.体外超声介导聚乙烯亚胺（PEI）转染 DNA 过程中声空化和声孔作用的相关性。
J Control Release. 2010 Jul 1;145(1):40-8. doi: 10.1016/j.jconrel.2010.04.010. Epub 2010 Apr 14.
10
Tuning payload delivery in tumour cylindroids using gold nanoparticles.利用金纳米颗粒调整肿瘤类圆柱体中的有效载荷输送。
Nat Nanotechnol. 2010 Jun;5(6):465-72. doi: 10.1038/nnano.2010.58. Epub 2010 Apr 11.
Zotero 插件