Rubin E H, Biggs J T, Preskorn S H
J Clin Psychiatry. 1985 Oct;46(10):418-24.
The pharmacokinetics of TCAs are reviewed with particular emphasis on nortriptyline, the agent most extensively studied. The clinical uses of TCA plasma level-response studies are discussed in relationship to rational dosage adjustment to increase response rates and avoid iatrogenic toxicity. Other important topics discussed include the issue of active metabolites, single-dose prediction studies, and special considerations in treating the elderly and the medically ill.
本文回顾了三环类抗抑郁药（TCA）的药代动力学，特别强调了去甲替林，这是研究最为广泛的一种药物。文中讨论了TCA血药浓度-效应研究在合理调整剂量以提高有效率和避免医源性毒性方面的临床应用。还讨论了其他重要主题，包括活性代谢物问题、单剂量预测研究以及老年患者和患有其他疾病患者治疗中的特殊注意事项。
