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直肠癌根治性直肠切除术后的低位前切除综合征:外科医生能产生有意义的影响吗?

Low Anterior Resection Syndrome following Restorative Proctectomy for Rectal Cancer: Can the Surgeon Have Any Meaningful Impact?

作者信息

Garfinkle Richard C, McKenna Nicholas P

机构信息

Division of Colon and Rectal Surgery, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA.

出版信息

Cancers (Basel). 2024 Jun 24;16(13):2307. doi: 10.3390/cancers16132307.

DOI:10.3390/cancers16132307
PMID:39001370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11240414/
Abstract

Postoperative bowel dysfunction following restorative proctectomy, commonly referred to as Low Anterior Resection Syndrome (LARS), is a common long term sequela of rectal cancer treatment. While many of the established risk factors for LARS are non-modifiable, others may be well within the surgeon's control. Several pre-, intra-, and postoperative decisions may have a significant impact on postoperative bowel function. Some of these factors include the extent of surgical resection, surgical approach, choice of anastomotic reconstruction, and use of fecal diversion. This review article summarizes the available evidence regarding how surgical decision-making can affect postoperative bowel function.

摘要

直肠切除术后的肠道功能障碍,通常称为低位前切除综合征(LARS),是直肠癌治疗常见的长期后遗症。虽然许多已确定的LARS风险因素是不可改变的,但其他一些因素可能完全在外科医生的控制范围内。术前、术中和术后的一些决策可能会对术后肠道功能产生重大影响。其中一些因素包括手术切除范围、手术方式、吻合口重建的选择以及粪便转流的使用。这篇综述文章总结了关于手术决策如何影响术后肠道功能的现有证据。

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Low Anterior Resection Syndrome following Restorative Proctectomy for Rectal Cancer: Can the Surgeon Have Any Meaningful Impact?直肠癌根治性直肠切除术后的低位前切除综合征:外科医生能产生有意义的影响吗?
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本文引用的文献

1
The effect of robotic surgery on low anterior resection syndrome in patients with lower rectal cancer: a propensity score-matched analysis.机器人手术对低位直肠癌患者低位前切除综合征的影响:倾向评分匹配分析。
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2
Sacral Neuromodulation in Patients With Low Anterior Resection Syndrome: The SANLARS Randomized Clinical Trial.骶神经调节治疗低位前切除综合征患者的随机临床试验(SANLARS)
Dis Colon Rectum. 2024 Mar 1;67(3):435-447. doi: 10.1097/DCR.0000000000003143. Epub 2023 Dec 11.
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Tumour-specific mesorectal excision for rectal cancer: Systematic review and meta-analysis of oncological and functional outcomes.直肠癌肿瘤特异性直肠系膜切除术:肿瘤学和功能结局的系统评价和荟萃分析。
Eur J Surg Oncol. 2023 Nov;49(11):107069. doi: 10.1016/j.ejso.2023.107069. Epub 2023 Sep 9.
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Low Anterior Resection Syndrome in a Reference North American Sample: Prevalence and Associated Factors.北美参考样本中的低位前切除术综合征:患病率及相关因素
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A novel nomogram to predict low anterior resection syndrome (LARS) after ileostomy reversal for rectal cancer patients.一种用于预测直肠癌患者肠造口还纳术后低位前切除综合征(LARS)的新型列线图。
Eur J Surg Oncol. 2023 Feb;49(2):452-460. doi: 10.1016/j.ejso.2022.10.015. Epub 2022 Oct 23.
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Patient-Reported Outcomes During and After Treatment for Locally Advanced Rectal Cancer in the PROSPECT Trial (Alliance N1048).在 PROSPECT 试验(Alliance N1048)中局部晚期直肠癌治疗期间和治疗后的患者报告结局。
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7
Long-term Quality of Life and Functional Outcome of Patients With Rectal Cancer Following a Watch-and-Wait Approach.直肠癌患者“观察等待”策略后的长期生活质量和功能结局。
JAMA Surg. 2023 May 1;158(5):e230146. doi: 10.1001/jamasurg.2023.0146. Epub 2023 May 10.
8
Reconstructive techniques following low anterior resection for carcinoma of the rectum: meta-analysis.直肠癌低位前切除术后的重建技术:荟萃分析。
Br J Surg. 2023 Feb 15;110(3):313-323. doi: 10.1093/bjs/znac400.
9
Neoadjuvant Chemotherapy, Excision, and Observation for Early Rectal Cancer: The Phase II NEO Trial (CCTG CO.28) Primary End Point Results.新辅助化疗、切除与观察治疗早期直肠癌:Ⅱ期 NEO 试验(CCTG CO.28)主要终点结果。
J Clin Oncol. 2023 Jan 10;41(2):233-242. doi: 10.1200/JCO.22.00184. Epub 2022 Aug 18.
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High Risk of Low Anterior Resection Syndrome in Long-term Follow-up After Anastomotic Leakage in Anterior Resection for Rectal Cancer.直肠癌前切除术后吻合口漏长期随访中低位前切除综合征的高风险。
Dis Colon Rectum. 2022 Oct 1;65(10):1264-1273. doi: 10.1097/DCR.0000000000002334. Epub 2021 Dec 15.