La'ah Anita Silas, Chiou Shih-Hwa
Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei 115, Taiwan.
Cells. 2024 Mar 1;13(5):436. doi: 10.3390/cells13050436.
Lung cancer remains a formidable global health challenge that necessitates inventive strategies to improve its therapeutic outcomes. The conventional treatments, including surgery, chemotherapy, and radiation, have demonstrated limitations in achieving sustained responses. Therefore, exploring novel approaches encompasses a range of interventions that show promise in enhancing the outcomes for patients with advanced or refractory cases of lung cancer. These groundbreaking interventions can potentially overcome cancer resistance and offer personalized solutions. Despite the rapid evolution of emerging lung cancer therapies, persistent challenges such as resistance, toxicity, and patient selection underscore the need for continued development. Consequently, the landscape of lung cancer therapy is transforming with the introduction of precision medicine, immunotherapy, and innovative therapeutic modalities. Additionally, a multifaceted approach involving combination therapies integrating targeted agents, immunotherapies, or traditional cytotoxic treatments addresses the heterogeneity of lung cancer while minimizing its adverse effects. This review provides a brief overview of the latest emerging therapies that are reshaping the landscape of lung cancer treatment. As these novel treatments progress through clinical trials are integrated into standard care, the potential for more effective, targeted, and personalized lung cancer therapies comes into focus, instilling renewed hope for patients facing challenging diagnoses.
肺癌仍然是一项严峻的全球健康挑战,需要创新策略来改善其治疗效果。包括手术、化疗和放疗在内的传统治疗方法在实现持续缓解方面已显示出局限性。因此,探索新方法涵盖了一系列有望改善晚期或难治性肺癌患者治疗效果的干预措施。这些开创性的干预措施有可能克服癌症耐药性并提供个性化解决方案。尽管肺癌新兴疗法迅速发展,但耐药性、毒性和患者选择等持续存在的挑战凸显了持续研发的必要性。因此,随着精准医学、免疫疗法和创新治疗方式的引入,肺癌治疗格局正在发生变化。此外,一种涉及将靶向药物、免疫疗法或传统细胞毒性治疗相结合的联合疗法的多方面方法,在解决肺癌异质性的同时,将其副作用降至最低。本综述简要概述了正在重塑肺癌治疗格局的最新新兴疗法。随着这些新疗法通过临床试验进展并融入标准治疗,更有效、有针对性和个性化的肺癌治疗的潜力成为焦点,为面临具有挑战性诊断的患者注入了新的希望。