Moretto Stefano, Saita A, Scoffone C M, Talso M, Somani B K, Traxer O, Angerri O, Liatsikos E, Ulvik Y, Cracco C M, Keller E X, Pietropaolo A, Tailly T, Corrales M, De Coninck V, Nagele U, Ferretti S, Kronenberg P, Carmignani L, Osther P J, Goumas I K, Ajayi L, Acquati P, Perez-Fentes D, Herrmann T R W, Buffi N M
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Department of Urology, Humanitas Clinical and Research Institute IRCCS, Rozzano, Italy.
World J Urol. 2024 Jul 13;42(1):412. doi: 10.1007/s00345-024-05103-0.
Iatrogenic ureteral strictures (US) after endoscopic treatment for urolithiasis represent a significant healthcare concern. However, high-quality evidence on the risk factors associated with US is currently lacking. We aimed to develop a consensus statement addressing the definition, risk factors, and follow-up management of iatrogenic US after endoscopic treatment for urolithiasis.
Utilizing a modified Delphi method, a steering committee developed survey statements based on a systematic literature review. Then, a two-round online survey was submitted to 25 experts, offering voting options to assess agreement levels. A consensus panel meeting was held for unresolved statements. The predetermined consensus threshold was set at 70%.
The steering committee formulated 73 statements. In the initial survey, consensus was reached on 56 (77%) statements. Following in-depth discussions and refinement of 17 (23%) statements in a consensus meeting, the second survey achieved consensus on 63 (86%) statements. This process underscored agreement on pivotal factors influencing US in endoscopic urolithiasis treatments.
This study provides a comprehensive list of categorized risk factors for US following endoscopic urolithiasis treatments. The objectives include enhancing uniformity in research, minimizing redundancy in outcome assessments, and effectively addressing risk factors associated with US. These findings are crucial for designing future clinical trials and guiding endoscopic surgeons in mitigating the risk of US.
经内镜治疗尿路结石后发生的医源性输尿管狭窄是一个重大的医疗问题。然而,目前缺乏关于与输尿管狭窄相关危险因素的高质量证据。我们旨在制定一份共识声明,阐述经内镜治疗尿路结石后医源性输尿管狭窄的定义、危险因素及随访管理。
利用改良德尔菲法,一个指导委员会基于系统的文献综述制定调查问卷。然后,向25位专家进行两轮在线调查,提供投票选项以评估一致程度。针对未解决的问题召开了共识小组会议。预定的共识阈值设定为70%。
指导委员会制定了73条声明。在初次调查中,56条(77%)声明达成了共识。在共识会议上对17条(23%)声明进行深入讨论和完善后,第二次调查有63条(86%)声明达成了共识。这一过程强调了在内镜治疗尿路结石中影响输尿管狭窄的关键因素上达成了一致。
本研究提供了经内镜治疗尿路结石后输尿管狭窄的分类危险因素综合清单。目标包括提高研究的一致性,减少结果评估中的冗余,并有效应对与输尿管狭窄相关的危险因素。这些发现对于设计未来的临床试验以及指导内镜外科医生降低输尿管狭窄风险至关重要。