Nielsen F H
J Nutr. 1985 Oct;115(10):1239-47. doi: 10.1093/jn/115.10.1239.
This review indicates that the lack of appreciation of, information about or understanding of the importance of diet composition has had a major influence on the development of knowledge about 11 ultratrace elements in nutrition. Inappropriate trace element supplementation and inadequate or unbalanced diets probably were responsible for many of the reported inconsistent and divergent findings, and thus, for the resultant controversy regarding the essentiality of specific ultratrace elements. Vanadium and nickel are taken as examples, and evidence is presented that variations in the concentrations of dietary components can affect the response of experimental animals to the various ultratrace elements. Furthermore, there is evidence that the ultratrace elements, given in sufficient quantity, can evoke pharmacological responses in animals. Failure to recognize these phenomena probably has led to a number of incorrect or biased interpretations of experimental results. Future research on the importance of ultratrace elements in nutrition requires close attention to an often neglected experimental variable--diet composition.
本综述表明，对饮食成分的重要性缺乏认识、了解相关信息或理解不足，对营养领域中11种超微量元素知识的发展产生了重大影响。不适当的微量元素补充以及饮食不足或不均衡，可能是许多报告中结果不一致和存在分歧的原因，因此也导致了关于特定超微量元素必要性的争议。以钒和镍为例，有证据表明饮食成分浓度的变化会影响实验动物对各种超微量元素的反应。此外，有证据表明，给予足够数量的超微量元素会在动物体内引发药理反应。未能认识到这些现象可能导致了对实验结果的一些错误或有偏差的解释。未来关于超微量元素在营养中重要性的研究需要密切关注一个经常被忽视的实验变量——饮食成分。
