Yin Renlin, Zhu Wei, Chen Weihai, Shen Jun, Wu Yanming, Wang Zhiming
Department of Cardiology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, China.
Department of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou, China.
BMC Cardiovasc Disord. 2025 Jan 31;25(1):64. doi: 10.1186/s12872-025-04507-z.
The relationship between several inflammatory biomarkers and slow coronary flow phenomenon(SCFP) has been reported. However, the correlation between neutrophil percentage-to-albumin ratio (NPAR) and SCFP is lacking. In this study, we aimed to assess the relationship between NPAR and SCFP.
A total of 228 patients were enrolled in this study according to the diagnostic and exclusion criteria. 76 patients were included in the SCFP group, and 152 age-matched patients were included in the normal coronary flow (NCF) group. The baseline data, laboratory parameters and coronary angiography were recorded and compared.
The values of NPAR were significantly higher in the SCFP group than those in the NCF group (1.78[1.58,1.88] vs. 1.42[1.24,1.66], P < 0.001). NPAR elevated as the number of vessels involved SCFP increased. In the multiple logistic regression tests, NPAR was an independent predictor of SCFP (OR: 1.239, 95%CI: 1.124-1.367, p < 0.001). The receiver operating characteristic curve analysis showed that the cutoff value of NPAR for predicting SCFP was > 1.57 with a 76.3% sensitivity and 67.1% specificity [the area under the curve (AUC) = 0.727, 95%CI: 0.659-0.795, p < 0.001]. NPAR had a better predictive value of SCFP than neutrophil percentage, but not albumin.
Elevated NPAR may be an independent and valuable predictor of SCFP.
已有报道称多种炎症生物标志物与冠状动脉血流缓慢现象（SCFP）之间存在关联。然而，中性粒细胞百分比与白蛋白比值（NPAR）和SCFP之间的相关性尚缺乏研究。在本研究中，我们旨在评估NPAR与SCFP之间的关系。
根据诊断和排除标准，本研究共纳入228例患者。SCFP组纳入76例患者，正常冠状动脉血流（NCF）组纳入152例年龄匹配的患者。记录并比较基线数据、实验室参数和冠状动脉造影结果。
SCFP组的NPAR值显著高于NCF组（1.78[1.58,1.88]对1.42[1.24,1.66]，P<0.001）。随着涉及SCFP的血管数量增加，NPAR升高。在多元逻辑回归分析中，NPAR是SCFP的独立预测因子（OR：1.239，95%CI：1.124-1.367，p<0.001）。受试者工作特征曲线分析显示，预测SCFP的NPAR临界值>1.57，敏感性为76.3%，特异性为67.1%[曲线下面积（AUC）=0.727，95%CI：0.659-0.795，p<0.001]。NPAR对SCFP的预测价值优于中性粒细胞百分比，但不如白蛋白。
升高的NPAR可能是SCFP的一个独立且有价值的预测因子。
