Department of Orthopedic Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China.
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education), Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China.
Cancer Commun (Lond). 2024 Sep;44(9):967-991. doi: 10.1002/cac2.12584. Epub 2024 Jul 14.
Bone is a common organ affected by metastasis in various advanced cancers, including lung, breast, prostate, colorectal, and melanoma. Once a patient is diagnosed with bone metastasis, the patient's quality of life and overall survival are significantly reduced owing to a wide range of morbidities and the increasing difficulty of treatment. Many studies have shown that bone metastasis is closely related to bone microenvironment, especially bone immune microenvironment. However, the effects of various immune cells in the bone microenvironment on bone metastasis remain unclear. Here, we described the changes in various immune cells during bone metastasis and discussed their related mechanisms. Osteoblasts, adipocytes, and other non-immune cells closely related to bone metastasis were also included. This review also summarized the existing treatment methods and potential therapeutic targets, and provided insights for future studies of cancer bone metastasis.
骨骼是多种晚期癌症（包括肺癌、乳腺癌、前列腺癌、结直肠癌和黑色素瘤）转移的常见器官。一旦患者被诊断出患有骨转移，由于广泛的病态和治疗难度的增加，患者的生活质量和总体生存率显著降低。许多研究表明，骨转移与骨微环境密切相关，尤其是骨免疫微环境。然而，骨微环境中各种免疫细胞对骨转移的影响尚不清楚。在这里，我们描述了骨转移过程中各种免疫细胞的变化，并讨论了它们的相关机制。还包括与骨转移密切相关的成骨细胞、脂肪细胞和其他非免疫细胞。本综述还总结了现有的治疗方法和潜在的治疗靶点，为癌症骨转移的未来研究提供了思路。
