School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China; Engineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei 230009, China.
Int J Biol Macromol. 2024 Sep;276(Pt 1):133844. doi: 10.1016/j.ijbiomac.2024.133844. Epub 2024 Jul 14.
Chlorella pyrenoidos polysaccharides (CPPs) are the main active components of Chlorella pyrenoidos. They possess beneficial health properties, such as antioxidant, anti-inflammatory, and immune-enhancing. This study aims to investigate the protective function and mechanism of CPPs against high-temperature stress injury. Results showed that supplementation with 20 mg/mL CPPs significantly extended the lifespan of Drosophila melanogaster under high-temperature stress, improved its motility, and enhanced its resistance to starvation and oxidative stress. These effects were mainly attributed to the activation of Nrf2 signaling and enhanced antioxidant capacity. Additionally, it has been discovered that CPPs supplementation enhanced Drosophila resilience by preventing the disruption of the intestinal barrier and accumulation of reactive oxygen species caused by heat stress. Overall, these studies suggest that CPPs could be a useful natural therapy for preventing heat stress-induced injury.
小球藻多糖（CPPs）是小球藻的主要活性成分。它们具有有益的健康特性，如抗氧化、抗炎和增强免疫力。本研究旨在探讨 CPPs 对高温应激损伤的保护作用和机制。结果表明，补充 20mg/mL 的 CPPs 可显著延长高温胁迫下黑腹果蝇的寿命，提高其运动能力，并增强其对饥饿和氧化应激的抵抗力。这些作用主要归因于 Nrf2 信号的激活和抗氧化能力的增强。此外，研究还发现，CPPs 通过防止肠道屏障的破坏和减轻热应激引起的活性氧积累，增强了果蝇的恢复能力。总的来说，这些研究表明 CPPs 可能是预防热应激损伤的一种有用的天然疗法。
