Key Laboratory of Pesticide & Chemical Biology (Ministry of Education), National Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction (Ministry of Education), College of Chemistry, Central China Normal University, Wuhan 430079, P.R. China.
Department of Chemistry, University of Rwanda, College of Science and Technology, Po. Box: 3900, Kigali, Rwanda.
Curr Top Med Chem. 2024;24(13):1101-1119. doi: 10.2174/0115680266280603240321064308.
This review highlights the advantages of combination therapy using polymer conjugates as drug delivery systems for cancer treatment. In this review, the specific structures and materials of polymer conjugates, as well as the different types of combination chemotherapy strategies, are discussed. Specific targeting strategies, such as monoclonal antibody therapy and small molecule ligands, are also explored. Additionally, self-assembled polymer micelles and overcoming multidrug resistance are described as potential strategies for combination therapy. The assessment of combinational therapeutic efficacy and the challenges associated with polymer conjugates are also addressed. The future outlook aims to overcome these challenges and improve the effectiveness of drug delivery systems for combination therapy. The conclusion emphasizes the potential of polymer conjugates in combination therapy while acknowledging the need for further research and development in this field.
本综述强调了聚合物缀合物作为癌症治疗药物递送系统的联合治疗的优势。在本综述中，讨论了聚合物缀合物的特定结构和材料，以及不同类型的联合化疗策略。还探讨了特定的靶向策略，如单克隆抗体治疗和小分子配体。此外，还描述了自组装聚合物胶束和克服多药耐药性作为联合治疗的潜在策略。还评估了组合治疗的疗效和与聚合物缀合物相关的挑战。未来展望旨在克服这些挑战并提高联合治疗药物递送系统的有效性。结论强调了聚合物缀合物在联合治疗中的潜力，同时承认需要在该领域进行进一步的研究和开发。
